Immune Rejection Articles & Analysis
6 articles found
NPs, for instance, once inserted into the body will be assessed and excised by the body's innards as foreign substances that generate immune responses and toxic effects. The NP recognition by the immune system and NPs synthesis by the reticuloendothelial system are the primary barriers to nano drug delivery to organs, tissues and lesions. ...
These products must not contain foreign substances, particularly host DNA, to avoid immune rejection and potential threats to life safety. Regulatory agencies worldwide have imposed strict limits on the amount of rcDNA, and various pharmacopoeias have outlined several reliable methods for residual DNA quantification, including threshold methods, hybridization ...
As a protein molecule related to chronic inflammation and immune injury, FGL2 can also promote the occurrence and development of tumors. ...
HYPOTHESIS: sustained therapeutic effect could be achieved by administration of IDUA-secreting allogeneic human cells shielded within spheres designed to avoid immune rejection and pericapsular fibrotic overgrowth ...
MPS I is caused by deficiency of the lysosomal enzyme a-L-iduronidase (IDUA) leading to GAG accumulation in multiple tissues and organs This accumulation results in a complex array of progressive, multi-systemic pathologies, including CNS manifestations Approved therapies include enzyme replacement therapy (ERT), with chaperone and gene therapies under investigation Treatment with approved ...
One issue with this treatment is the widespread potential for “immune rejection” where the body sees the islets as foreign and tries to destroy them. ...