In Vitro Experiment Articles & Analysis
11 articles found
It has been established in vivo and in vitro experiments and reviews that dual-target peptide-modified RBCNPs exhibit better targeted uptake of gliomas than nanoparticle-based drug delivery systems, with beneficial and safe therapeutic outcomes, which indicates the high potential of bionic nanomaterials in the treatment of tumors. ...
In this study, the researchers used the estrogen receptor protein (ERα) as a model and confirmed the significant degradation of ERα in in vitro experiments using this system. In recent decades, PROTACs have become an attractive technology in drug development. ...
While KineTAC demonstrated excellent results in in vitro experiments, its in vivo experiments have not been extensively explored. Only pharmacokinetic studies have been presented, leaving room for further animal experiments to validate whether the in vitro effective dose might lead to potential "cytokine storm" ...
Among them, Sibylla has already found 35 promising molecules, including some belonging to the hydroxychloroquine family, suspected of being capable of blocking viral replication in vitro. This molecule, its six analogues and the other 35 predicted by the calculations will be further evaluated in the laboratory. The activity of hydroxychloroquine and its analogues on COVID-19 is ...
Then, the researchers analyzed the ability of a group of cysteine-reactive ligands to bind OTUB1 and identified acrylamide EN523 as the first choice. In vitro experiments showed that EN523 was specifically bound to the allosteric C23 site of OTUB1, and OTUB1 activity was not lost after binding. ...
Ser189 was identified as the glycosylation modification site of MDH1 by high-resolution mass spectrometry combined with point mutation. In vitro enzyme activity experiments showed that glycosylation at Ser189 could enhance its enzyme activity. Targeted metabolomics experiments confirmed that MDH1 glycosylation promotes Gln metabolism and NADPH ...
The IE gene induces the expression of early genes such as BMR F 1, B A L F 2 and B H R F 1 genes. In vitro experiments inferred that BRRF1 may activate transcription in a promoter- and cell-type-dependent manner. ...
The BVP can then be anastomosed as an arterial (or arteriovenous) graft, which allows fully oxygenated arterial blood with a pO2 of roughly 100 mmHg to flow through the graft lumen and thereby supply oxygen to the islets. In silico simulations and in vitro bioreactor experiments show that the BVP design provides adequate survivability for islets and helps avoid ...
Plasma comprises charged particles as well as a range of other active components that are thought to interact with the body to produce desired affects in plasma medicine such as; electric current, UV radiation and reactive gas species these components are thought to be able to act synergistically. In in vivo and in vitro experiments, anti-inflammatory, ...
Results Feed homogenates from theTreatment I (NC) remained PRRSV PCR negative throughout the 0-21 d in vitro experiment. For the Treatment 2 (PC), all replicates of feed homogenates collected during the in vitro experiment were PRRSV PCR positive with an average Ct of 22.1 at Oh and 22.3-23.9 during ld-2ld. For theTreatment 3 ...
Several studies, performed both through Monte Carlo simulation of dosimetric and microdosimetric enhancement in presence of GNPs and through in–vitro experiments, have clearly shown the powerfulness of such a technique in radiotherapy. ...