In Vitro Test Articles & Analysis
20 articles found
These approaches often include in vitro and in vivo testing, as well as computational modeling. In vitro testing involves studying immune responses in controlled laboratory environments using cell cultures. ...
In the realm of pharmaceutical research and development, ADME testing services play a pivotal role in evaluating the pharmacokinetics of drug candidates. ...
Recognizing the need for a more accurate and efficient evaluation system, the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative emerged. At the heart of this initiative are CiPA Translational Assays, designed to improve the prediction of drug-induced cardiac arrhythmias. ...
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
CellRight Technologies® uses a proprietary demineralization process designed to preserve native BMP’s, as demonstrated in their osteoinductive testing. Every lot of ACTIGEN™ Verified Inductive Bone Matrix is verified for osteoinductivity post sterilization as a condition for distribution. In-vivo test results have histologically demonstrated the ...
We use a guinea pig maximization test, closed patch test or murine local lymph node assay to detect the sensitization of medical devices. ...
BetaLifeScience provides high-quality MMP-3 antigens and antibodies that have been validated on LF (Lateral Flow) and CLIA (Chemiluminescent Immunoassay) platforms, contributing to the development of in vitro diagnostic test kits. High affinity reaching pM level Strong stability, validated through freeze-thaw and accelerated stability testing ...
The Al-designed antibodies were tested in vitro and demonstrated high potency against multiple strains in real virus neutralization assays. ...
The GST pull-down experiment is an effective in vitro test technique to verify the yeast two-hybrid system. The basic principle is to construct the target protein-GST fusion protein vector first, and then perform in vitro expression and purification. ...
Our goal in design is to find a set of promising variants that’s small enough to test in vitro/vivo (scale) while maximizing the fraction of capsids in this set which are viable (efficiency). ...
Gene-Editing Opportunities for RepliGut® Models Altis Biosystems has developed RepliGut®, a next-generation commercial intestinal tissue model platform for in vitro testing during drug development and for basic science applications. ...
RepliGut® tissue constructs have been designed to meet this need. Lack of Robust in Vitro Gut Models Very few in vitro models available accurately represent the gut. ...
MedBiome’s founders reported in Microbiome the development of the RapidAIM platform to screen compounds against individual microbiomes in vitro. They tested 43 compounds (including 4 antibiotics) against 5 individual microbiomes using the RapidAIM technology. ...
Active PDE then hydrolyzes antiinflammatory cAMP to facilitate inflammatory signaling. To test this model in vivo, we mutated the integrin binding site of PDE4D5 in mice. ...
In this study we evaluated (1) the efficacy of a protocol that combines hydrogen peroxide (shock treatment) and ICX® tablets (continuous treatment) for the control of microbial contamination in dental unit water lines, and (2) the in vitro antimicrobial activity of ICX® tablets on collection and wild strains isolated from dental chair output waters. To assess the treatment ...
Endocrine disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic‐pituitary‐gonadal (HPG) axis. While in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro response to in vivo action shows inconsistent accuracy. ...
The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish (Danio rerio) in the Fish Sexual Development ...
Abstract Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. Experimental design: We ...
Norovirus is the leading cause of food-related illness in the United States, and contamination of ready-to-eat items by food handlers poses a high risk for disease. This study reports the in vitro (suspension test) and in vivo (fingerpad protocol) assessments of a new ethanol-based hand sanitizer containing a synergistic blend of polyquaternium polymer and ...
On April 26, 2004, the United States Environmental Protection Agency (EPA) issued a final rule under the Toxic Substances Control Act (TSCA) requiring manufacturers and processors of 34 chemicals to conduct in vitro dermalabsorption-rate testing. OSHA has identified the data necessary for these chemicals and intends to use the data obtained under the rule to ...