In Vivo Data Articles & Analysis
10 articles found
They bridge the gap between simple in vitro tests and complex in vivo studies. By integrating data from multiple ion channel assays and leveraging computational modeling, translational assays offer a comprehensive view of a compound’s electrophysiological impact on the heart. ...
AFM13 showed single agent clinical activity with solid safety profile in a Phase 1 study2. Pre-clinical in vivo data of the combination of AFM13 with PD1-blockade showed synergism and the potential for induction of cross-talk between innate and adaptive immunity.3 Based on these findings, we conducted a Phase 1b study evaluating the safety and tolerability of ...
Now, we are extending our industrialized approach to petabytes of pre-clinical in vivo studies. Digitalizing in vivo studies could further speed up our science by reducing the time needed to gather and act on insights, increasing the precision of studies, and improving translatability to clinical outcomes. In vivo studies provide the first ...
Existing methodologies for PK characterization typically rely on in vivo studies in mice, rats and dogs4. Animal models are the current gold standard for conducting these PK predictions, however, they suffer from an overall low relevance to in vivo clinical studies, as evidenced by the current 92 percent failure rates of compounds that enter the clinic; and of ...
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. ...
Experience: Find your carrots Biologists in a global pharmaceuticals company were capturing and managing preclinical in vivo data with ad-hoc and Excel-based approaches. They were comfortable with this approach, but this made this critical data hard to find, hard to understand and hard to reuse by the modellers who wanted to introduce better ...
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in ...
The approach was based on: 1) inclusion of relevant chemical classes supported by high‐quality in vivo data for bioconcentration factor (BCF), whole body biotransformation rates (Kmet) and metabolism characterisation for rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio) (Tier I‐II); and 2) refinement to ensure a broad coverage of ...
Mixing techniques used to reduce porosity in bone cement demonstrate large improvements in fatigue behaviour in test specimens, but do not appear to reduce the rate of loosening of implants in vivo. We examined data showing the effect of notches on fatigue strength and found, surprisingly, that notches with low stress-concentration factors (Kt Keywords: mixing ...
We also show that ddb1+ and the putative CSA homolog ckn1+ are involved in transcription-coupled nucleotide excision repair and that the DDB-box is essential for the ckn1+ function in vivo. These data indicate that the DDB-box is another common motif which defines adaptor proteins for DDB1/cullin 4 ubiquitin ...