In Vivo Efficacy Articles & Analysis
4 articles found
Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be achieved in mice and cell culture systems. A wide range of assays can be ...
Copper-Free Click Chemistry for Imaging The biocompatibility and selectivity of copper-free click chemistry have facilitated its application in in vivo imaging. For example, dibenzocyclooctyne (DBCO) click chemistry reagents can be used in the development of bioorthogonal probes and contrast agents for in vivo imaging applications. ...
This linker exhibits low levels of aggregation, high plasma stability, and strong in vivo efficacy. The linker is also applied to other amine-containing payloads through an additional dimethylethylenediamine (DMED) self-degrading spacer, such as Camptothecins, SN38, Duocarmycins, and Matrine. ...
Biological Analysis of ADC In order to characterize the PK characteristics of different ADC components, several analytical methods are required: (1) ELISA determines the kinetic curves of the conjugate and total antibody. (2) TFC-MS/MS can quantify the free drugs or metabolites. (3) High-resolution mass spectrometry for in vivo drug antibody ratio (DAR) analysis. In addition, two ...