In Vivo Fish Bioaccumulation Tests Articles & Analysis
14 articles found
Immunotoxicology is a specialized field that focuses on the assessment of how chemical substances affect the immune system. With the advancement of pharmaceuticals, environmental pollutants, and industrial chemicals, the need for comprehensive immunotoxicological evaluations has become paramount. This article explores the significance of immunotoxicology services, their methodologies, and their ...
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be ...
Background CellRight Technologies® has developed ACTIGEN™ Verified Inductive Bone Matrix, a dehydrated, verified inductive matrix that may be hydrated with saline, blood, Bone Marrow Aspirate (BMA), Platelet Rich Plasma (PRP), or other cellular components in accordance with a physician’s well-informed medical judgment. The clinician may add allograft or autograft to ...
Medical device biocompatibility testing is a quality control standard for the development and manufacturing of medical devices. Biocompatibility testing evaluates the effect of a medical device on human tissues to determine whether it can cause biological reactions such as toxicity, physiological, immune, or mutation. Biocompatibility testing is a key process to ensure the safety and ...
Introduction In the ever-evolving landscape of drug delivery systems, nanoformulation stands out as a revolutionary approach. Nanoformulation leverages nanotechnology to create drug delivery systems that can improve the efficacy, reduce side effects, and precisely target disease sites. This cutting-edge technology has garnered significant attention from researchers and pharmaceutical companies ...
The following publication describes a study developing the ROP-TB antigen for both in vitro IGRA-based TB diagnosis, as well as the in vivo skin test for TB diagnosis in both humans and cattle. The advantages of the ROP-TB diagnosis are firstly distinguishing Mtb infection from BCG vaccination, and secondly, being suitable for industrial manufacture. Read the full article: ROP-TB Diagnosis ...
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. Organ-on-a-chip models are the closest ...
There are now nearly 230 million patients with osteoarthritis in the world and 4 million additional cartilage lesions per year. Osteoarthritis results anatomically in the destruction of cartilage in the joints (knee, hip, etc.), which causes severe pain and a significant reduction in mobility. ACS Biotech is an innovative biotechnology company created in 2013 by Pascale Hazot, Doctor of ...
Abstract Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site, S651. Active PDE then hydrolyzes antiinflammatory cAMP to ...
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro high‐throughput assays for specific ...
The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish (Danio rerio) in the Fish Sexual Development Test (OECD TG 234) and a 12 day adult male ...
The aim to reduce the number of animals in experiments has highlighted the need to develop and validate non‐animal methods as alternatives to bioaccumulation studies using fish. The present study details a novel 3‐tier approach to develop a list of reference compounds to aid this process. The approach was based on: 1) inclusion of relevant chemical classes supported by high‐quality in vivo ...
Numerous chemical and physical methods have been employed to prepare metal nanoparticles, including chemical reduction. Silver has been known to have potential for bactericidal properties and promotion of wound healing. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. We used chemical reduction for preparation of ...
Abstract Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. Experimental design: We tested in vitro ...