Inflammatory Bowel Articles & Analysis
26 articles found
Functionally, TREM1 acts as an amplifier of inflammatory responses. Upon activation, it potentiates the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), thereby exacerbating the inflammatory cascade. ...
Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to regulate the development of the intestine and the inflammatory response of the body. Inflammatory responses in the body, etc. ...
Typically, this cell-specific uptake is mediated by ligand-receptor interactions, but recent research has found that this interaction can also be achieved by altering the lipid structure within the LNP. 1) White blood cell-targeted LNP In order to achieve cell-specific mRNA therapy for inflammatory bowel disease (IBD), researchers prepared antibody-modified LNP ...
In a clinical context, MSCs are instrumental in treating osteoarthritis, inflammatory bowel disease, graft-versus-host disease, myocardial infarction, and more. ...
The adenosine produced through these processes exerts potent anti-inflammatory effects. It achieves this by binding to the adenosine A2A receptor (ADORA2A), which is expressed by various immune cells like T cells, natural killer (NK) cells, and dendritic cells (DCs). ...
It usually binds to its inhibitory protein in a non-activated state in the form of P50-P65 dimer. Many inflammatory responses are strongly associated with NF-κB activation. By combining CPP (8K, octa-yLysine) with NF-κB essential regulator binding domain (NBD), Dave et al. treated mice with inflammatory bowel disease by ...
Cytokines in Cytokine Release Syndrome (CRS) CRS, a systemic inflammatory reaction stemming from diverse triggers such as infections, autoimmune inflammation, and medical causes, involves various cytokine classes including inflammatory effectors, initiators, modulators, chemokines, and colony-stimulating factors. ...
The binding of IL-36 Ra to IL-1R6 does not lead to the recruitment of IL-1RAcP. Therefore, the pro-inflammatory cascade reaction is not initiated, realizing the anti-inflammatory characteristics of IL-36 Ra. ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. ...
Application in the diagnosis and prognosis determination of small intestinal clonorchiasis Small bowel clonorchiasis is an inflammatory disease of the intestine of unknown origin. It and chronic non-specific ulcerative colitis are collectively known as inflammatory bowel disease (IBD). The disease is active with shortening and ...
It’s reported that persistent activation of NF-κB can lead to chronic inflammation, such as rheumatoid arthritis, Parkinson's disease, and inflammatory bowel disease. However, NF-κB activation requires interactions with NF-κB essential modulators and kinase complexes. A test was carried out by combining CPP (8K, Octylysine) with ...
The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. While immunotherapy in combination with anti-pd-1 and anti-ctla-4 agents has revolutionized the treatment of multiple cancer types, it also has high toxicity, which may impact quality of ...
We maintain our commitment to their diagnosis, with kits for the in vitro diagnosis of the following rare diseases*: Rare Disease : Diagnostic tests Cystic fibrosis or fibrocystic disease of the pancreas : Determination of 50 cystic fibrosis mutations in patients and relatives by genetic analysis Multiple sclerosis : Determination of anti-ganglioside and anti-myelin-associated glycoprotein ...
Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of intestinal epithelia can disrupt the intestinal barrier via mechanisms including that activation of ...
Observational study with retrospective and prospective data collection, for total of 24 months. This is an IBD technology study investigating quantitative metrics for endoscopy, histology and radiology for improved diagnosis and assessment of ...
The authors report that STAT1KO mice spontaneously develop inflammatory diseases characterized by bone marrow hyperplasia and splenic accumulation of hematopoietic stem cells. In addition, these animals developed inflammatory bowel disease. Analysis of intestinal bacteria revealed severe dysbiosis in the absence of potent IFN signaling, which ...
Their relative population size is dynamic, depending on the state of the body (inflammatory bowel disease, diabetes, etc.). The intestinal microecosystem is rich in various compounds secreted by the host, such as glycoproteins, saliva, gastric juice, bile salts and mucus, and consumes about 1.5 kg of amino acids, short-chain fatty acids and dietary fiber from ...
There is a lot of interest in using cells from an inflammatory bowel disease (IBD) donor in the RepliGut® model, but since IBD is not well understood, there is no assurance that the cells would continue to have an IBD phenotype. ...
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to accurately recapitulate the complex ...
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. ...