Influenza A Virus Articles & Analysis: Older
20 articles found
Researchers are working on mRNA vaccines for influenza, Zika virus, and even HIV. In 2024, we can expect to see clinical trials that leverage this technology, aiming for a more efficient and rapid response to viral outbreaks. ...
Welcome to 2023-2024 season’s respiratory surveillance recap, where we’ll share insights from the most recent respiratory surveillance season, covering three major respiratory viruses: COVID-19, influenza, and RSV. Tracking these illnesses is imperative for maintaining population health because these illnesses significantly impact individual wellbeing and healthcare costs, resource ...
Evaluating the stress related effects of various restraint methods in rodents Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. For nose-only inhalation set-ups, typical restraints are rigid, fully enclosed and include a metal or acrylic plunger forcing the subject forward and preventing the subject from ...
The rapid accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (Raf/MEK/ERK) signaling pathway represents one of those targets for broad-spectrum antiviral drug development as it is exploited by many viruses during their replication cycle, e.g., coronaviruses, Ebola virus, hepatitis C virus, respiratory syncytial ...
These symptoms usually begin from 1-4 days (most commonly 1-2 days) after exposure to the virus and last for about 2-8 days[1]. There are four types of influenza virus: A, B, C, and D. Of these, the influenza A virus is responsible for most cases of severe illness, seasonal epidemics and occasional pandemics. ...
Respiratory syncytial virus, influenza virus, parainfluenza virus, adenovirus, rhinovirus, and coronavirus belong to the respiratory virus infections group. ...
Similar concerns extend to other viral pathogens such as influenza virus, respiratory syncytial virus (RSV), and the next novel human respiratory virus we will encounter. ...
Using influenza virus as a model virus, the team established the technology of protein degradation targeting virus as an attenuated vaccine (Proteolysis-Targeting Chimeric virus vaccine, PROTAC vaccine), which provides new ideas for vaccine development. ...
A variety of viruses such as SARS-CoV, influenza A (H1N1) virus, and MERS-CoV can cause cytokine storms after infection of humans. ...
Making influenza vaccines that can help protect against viruses that threaten human health isn’t a simple process. It requires the cooperation between influenza vaccine manufacturers like Seqirus, and the World Health Organization’s (WHO) 158 laboratories in 127 countries and 7 collaborating centers that comprise its Global Influenza ...
The study will evaluate subjects’ ability to raise mucosal antibodies in the nasal passages, serum antibodies against matched and drifted strains of the influenza virus, and cellular immune responses. In a prior Phase 2 drifted H3N2 challenge trial, M2SR demonstrated efficacy against infection and illness across seven years of flu virus ...
Wastewater & COVID-19 Connections When the word wastewater crosses your mind, there is probably also a memory of your Mom’s voice telling you – wash your hands! When humans transitioned into community living, keeping your living space separate from your bathroom space was an important rule to learn. We can thank early scientists who were curious about how diseases spread and ...
“Current vaccines are strain-specific and in recent years they have had low efficacy against H3N2 influenza, especially when the vaccine is mismatched to circulating virus,” said Dr. ...
The study will evaluate subjects’ ability to raise antibodies against matched and drifted strains of the influenza virus. The extent to which all major components of the adaptive immune system are activated will also be measured. In a prior Phase 2 drifted H3N2 challenge trial, M2SR demonstrated efficacy against infection and illness across seven years of ...
As early as the 1940s, American scientist George Hirst discovered a substance that destroys receptors on the surface of red blood cells in a sample of influenza virus mixed with red blood cells (red blood cells). Since then, British biochemist Alfred Gottschalk discovered that these receptor-damaging enzymes are neuraminidase. ...
Based on an invention by UWMadison virologists and FluGen co-founders Yoshihiro Kawaoka and Gabriele Neumann, M2SR is a self-limiting version of the influenza virus that induces an immune response against the flu. Kawaoka’s lab will insert gene sequences from SARS-CoV-2, the novel coronavirus that causes the disease COVID-19, into M2SR so that the new ...
Abstract Both influenza A and B viruses cause outbreaks of seasonal influenza resulting in significant morbidity and mortality. There are two antigenically distinct lineages of influenza B virus, Yamagata lineage (YL) and Victoria lineage (VL). Since both B lineages have been co-circulating for years, more than 70% of ...
However, gastrointestinal symptoms developed in a large proportion of influenza A (H1N1) 2009 virus infected people during the pandemic in 2009 and fecal shedding was reported. ...
We present our methodology and stochastic discrete-event simulation developed to model the screening of passengers for pandemic influenza at the US port-of-entry airports. Our model uniquely combines epidemiology modelling, evolving infected states and conditions of passengers over time, and operational considerations of screening in a single simulation. ...
Additionally, to date there are no vaccines or antiviral drugs for most common enteric and respiratory viruses with the exception of influenza virus and hepatitis A virus (HAV). Consequently, viral disease spread is most effectively deterred by preclusion of viral ...