Insulin Resistant Articles & Analysis
23 articles found
Weight and sleep interconnected and that fact is oftentimes overlooked. If you are having issues sleeping or wake up frequently at night, did you gain weight recently? If you have, you are not alone. Many studies have shown that weight gain does lead to poor sleep and can impact REM sleep, due to hormonal imbalances and sleep disorders, such as sleep ...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. Understanding this condition is crucial for effective intervention and treatment. ...
Do you have fragmented sleep all through the night? Do you wake up oftentimes at night, struggling to breathe? Is your partner tired of your heavy snoring and often reminds you to see a doctor? Well, if your chronic, frequent snoring is associated with sleep apnea, there are a number of factors and issues to be aware of. Basically, it’s a matter of cause and effect with sleep apnea ...
When fed a high-fat diet, germ-free mice were resistant to the obesity phenotype, while germ-free mice had lower plasma triglyceride and low-density lipoprotein levels compared to mice with normal flora, due in part to reduced lipid digestion, absorption and transport. ...
Preventing lipid peroxidation. Increasing insulin receptor expression or affinity, enhancing insulin sensitivity. ...
Type 1 Diabetes Mellitus Models Type 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of insulin-producing beta cells in the pancreas, resulting in a complete deficiency of insulin. ...
Type 1 diabetes (once known as insulin-dependent diabetes or juvenile onset diabetes) is characterized by insufficient insulin production and the need for daily insulin intakes, and it is unclear what causes it. ...
In addition, our previous study also found that tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases, and has a wide range of application prospects. 1.Hypoglycemic Effect Murugan P et al. induced type 2 diabetes mouse model with streptozocin, and then ...
In addition to diabetes’ effect on the systemic inflammatory state, the condition can also contribute to the development of HFpEF through other pathways, such as accelerating atherosclerosis, leading to myocardial ischemia. [41] Volume overload can also result from the progressive renal dysfunction associated with diabetes. Hyperglycemia and insulin ...
Sleep is an important factor to help maintain health and well-being. It’s recommended that an adult should get at least 7 hours of sleep a night. Getting a good night’s sleep has many benefits such as better memory, reduced stress levels and lowers the risk of heart disease. On the flip side, not getting enough sleep regularly can have serious repercussions such as a weaker immune ...
Obesity is a major risk factor for diabetes and leads to insulin resistance that often precedes diabetes. Currently, genome-wide association studies (GWAS) have identified more than 80 diabetes susceptibility loci, and an increasing number of mutations and variants have been identified in monogenic forms of diabetes, such as young adult-onset diabetes (MODY). ...
The main mechanisms by which ceramide regulates the development of obesity and related diseases are as follows: ceramide inhibits insulin signaling and hinders glucose metabolism; induces apoptosis; impairs mitochondrial function and induces mitochondrial autophagy. ...
In other chronic diseases like diabetes, global sequencing analysis has revealed that lncRNAs are associated with pancreatic β-cell disease, insulin resistance and other complications. As the information about lncRNAs and their role in disease continues to be decoded, lncRNAs not only have become important targets for studying pathogenesis and progression ...
Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. ...
Insulin Therapy Insulin therapy, taken by injection, is the most common medication doctors prescribe for those with type 1 diabetes whose bodies cannot make their own insulin. ...
Patients with established or pre (type -2) diabetes In which the presence of autoantibodies in addition to insulin resistance may predict a more rapid progression to insulin deficiency. ...
ByIUL S.A.
To confirm the alleviating effect of R. faecis on liver damage in other mouse NAFLD models, we used a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) model which prevents body weight loss in mice and shows no insulin resistance, and a genetic leptin-deficient (db/db) model, which develops spontaneously diabetes and fatty liver with ...
The condition is also closely linked to metabolic syndrome, a condition that is a combination of cardiovascular and blood sugar control symptoms such as elevated blood pressure, elevated blood fats, insulin resistance, elevated blood sugar and increased abdominal fat. ...
ByAlgatech
Clamp studies work by varying an infusion of glucose or insulin so that blood glucose concentration is maintained (clamped) at a specific level. This quantifies the reaction to glucose or insulin, (usually how sensitive an individual is to insulin or to how well someone metabolises glucose). They're also regularly used in the development of ...
Previously, we demonstrated that SRSF3 regulates splicing of the insulin receptor gene (INSR) (8) and plays an important role in hepatocyte differentiation and hepatic glucose and lipid metabolism (9). ...