Insulin Secretion Articles & Analysis
9 articles found
These oral antidiabetic medications mainly work by increasing insulin sensitivity, slowing down the metabolism of carbohydrates in the small intestine, repairing and improving the function of pancreatic β-cells, and promoting insulin secretion to achieve blood glucose reduction. ...
Abstract C-peptide is co-secreted with insulin and is not subject to hepatic clearance and thus reflects functional β-cell mass. ...
Introduction of Diabetes Diabetes is a serious chronic disease characterized by elevated blood sugar concentrations associated with the effects of abnormal beta cell biology on insulin action. Diabetes occurs when the pancreas does not produce enough insulin or the body does not use the insulin it does produce efficiently. ...
In addition, our previous study also found that tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases, and has a wide range of application prospects. 1.Hypoglycemic Effect Murugan P et al. induced type 2 diabetes mouse model with streptozocin, and then treated with ...
It is important to note that SGLT2 inhibitors are safe because their hypoglycemic effect is insulin-independent and fasting increases compensatory production of hepatic endogenous glucose. ...
Type 1 diabetes (T1D) is a complex T-cell-mediated autoimmune disease that results in the destruction of insulin-producing beta cells and inadequate insulin secretion. Prior to the discovery of insulin in 1921, patients with T1D died within a year or two of diagnosis. Since the discovery and mass production of ...
Half of all transplanted patients are back on insulin injections one year later and 90% revert to insulin dependency within five years. ...
Betalin Therapeutics has developed the first bio-artificial pancreas, composed of pig’s lung tissue and insulin secreting cells. The artificial pancreas would be implanted into the patient and connect with his or her blood vessels, and then be able to measure the body’s sugar level and secrete an optimal amount of ...
Clamp studies work by varying an infusion of glucose or insulin so that blood glucose concentration is maintained (clamped) at a specific level. This quantifies the reaction to glucose or insulin, (usually how sensitive an individual is to insulin or to how well someone metabolises glucose). They're also regularly used in the development of ...