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Melanoma Articles & Analysis
27 articles found
These rays are responsible for sunburn and play a critical role in the development of skin cancer, including melanoma. Unlike UVA, UVB intensity varies by season, location, and time of day, typically peaking between 10 AM and 4 PM. ...
The IP10-loaded platelets targeted and inhibited tumor cells in the B16F10 melanoma model and lessened immunosuppressive regulatory T cell activity through CD40L activation on platelet membranes which led to boosted anti-tumor immunity. ...
Researchers utilize these cells to explore the efficacy of drugs, assess toxicology, and understand the underlying mechanisms of skin diseases such as fibrosis, psoriasis, and melanoma. Furthermore, they are employed in the production of skin substitutes in regenerative medicine, offering hope for better treatments in skin grafting and reconstructive surgeries. ...
The tumor cell membrane is coated with PLGA nanoparticles, and a nanovaccine based on PLGA as the core is constructed, which can be used to fight melanoma B16 of ...
Prominent tumor-associated antigens include mucin-1 (MUC1), human epidermal growth factor receptor 2 (HER-2), cancer-testis antigen 1 (NY-ESO-1), T cell-recognized melanoma antigen 1 (Melan-A or MART-1), prostate-specific antigen (PSA).AntifungalEradicating invasive fungal infections often requires months to years of continuous drug administration, increasing the risk of ...
Researcher Insco said that we found that CDK13 protein can play the role of tumor suppressor in melanoma, and its mutation or deletion can lead to tumor occurrence. By analyzing the data of melanoma patients and the Zon zebrafish model, the researchers clarified that the reason for inducing CDK13 protein deletion or mutation, and revealed its molecular mechanism ...
Findings were then validated in cryopreserved peripheral blood mononuclear cell samples from the same study, as well as an independent CyTOF dataset from a published metastatic melanoma trial. Together, these results not only establish FAUST as a powerful new approach for unbiased discovery in single-cell cytometry but also indicate that a population of effector memory CD4+ and ...
What’s the diagnosis? Acral lentiginous melanoma Atypical nevus Talon noir Tinea nigra Use the Differential Builder in VisualDx to help you. ...
ByVisualDx
(“Aesther”) (NASDAQ: AEHA) announced today the discovery of bispecific antibodies that target Chitinase 3-like-1 and immune checkpoint inhibitors, killing glioblastoma cells and melanoma cells, and blocking the metastasis of malignant melanoma cells to the lung by over 90%. ...
More importantly, this new therapy has been validated in mouse solid tumor models of melanoma and pancreatic cancer, providing new strategies for the study and application of adoptive T cells in the treatment of solid tumors. ...
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. ...
"We first need to overcome immunotoxicity to support patients and reduce their symptom burden," said senior author Adi Diab, MD, associate professor of medical oncology in melanoma. “Second, we know that there are multiple non-overlapping resistance mechanisms in the tumor microenvironment. ...
Opdualag therapy is a fixed-dose combination of Relatlimab (anti-LAG3) and Nivolumab (anti-PD1) for the treatment of adult and pediatric patients 12 years of age and older with unresectable or metastatic melanoma, making LAG-3 the third immune checkpoint in the clinic after PD-1 and CTLA-4. ...
The whole exome sequencing panel has been used to identify and evaluate rare mutations associated with colorectal cancer, pancreatic cancer, and melanoma, ...
Dr. Kandace P. McGuire shares how 3D tomosynthesis assisted her during two cases (The Case of the Missing Magseed & Imaging a Bracketed Lesion). In addition, Dr. McGuire discusses how she evaluated the specimens in multiple ways using KUBTEC’s MOZART ...
Recent studies have found that PTGDS is overexpressed in malignant melanoma, ovarian cancer, and hepatocellular adenoma. In contrast, other researchers found that PTGDS was downregulated and inhibited tumor progression in prostate tumors, lung tumors, and gastric cancer. ...
Drugs called immune checkpoint inhibitors have provided life-saving benefits to more and more people suffering from melanoma, lung cancer, bladder cancer, and many other types of cancer. ...
A breakthrough in nanotechnology accelerates vaccine production While COVID-19 hotspots have continued to emerge driven by the Delta variants, the data still shows that vaccinations are effective at preventing hospitalizations and deaths. While over 4 billion vaccine doses have been administered worldwide, only 27% of the world’s population and only 1.1% of people in low-income countries ...
Treos is also developing “off-the-shelf” personalized immunotherapies (PEPI Panel) for several types of solid tumors and has completed preclinical development of PolyPEPI immunotherapies in ovarian, breast, bladder, gastric and lung cancers and melanoma. The Company is also developing an investigational COVID-19 peptide vaccine, PolyPEPI-SCoV-2. ...
Increased risk of different cancer types in workers employed in petroleum industries and residents living in oil producing communities by Felix Onyije, Bayan Hosseini, Kayo Togawa, Joachim Schüz, and Ann Olsson Considerable health conditions are caused by environmental pollutants, including emissions from petroleum extraction and refining. They are major sources of environmental and ...