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Metabolic Engineering Articles & Analysis: Older
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Another emerging method involves the direct fermentation of metabolic-engineered microorganisms, utilizing natural and novel pathways to produce ethylene glycol from monosaccharides.Bio-based TPA technology is still in the developmental stage. ...
Such models play a crucial role in better understanding the pathophysiology of diabetes, evaluating novel therapeutic strategies, and predicting the short- and long-term outcomes of different treatments on glucose metabolism and diabetes-related complications. Metabolic Disease Models Metabolic diseases encompass a wide range of conditions ...
These bioorthogonal reactions find extensive applications in various fields, including radionuclide conjugate, metabolic engineering, drug target identification, medicinal chemistry, and more. ...
At the same time, it is impossible to predict the effects of mutations on other metabolic processes in an organism. In this case, recombinant DNA technology (RDT) was developed. ...
Predicting metabolic models in the early stage of drug discovery is of great significance to improve the success rate of drug discovery. ...
Recently, Gregory Stephanopoulos, the Willard Henry Dow Professor in Chemical Engineering at MIT; postdoc Amit Kumar PhD ’10, also of the Department of Chemical Engineering; and their team released a paper in the Proceedings of the National Academy of Sciences. ...
However, the application of biosurfactants is limited by the availability of economic biosurfactants and the corresponding producers that can work effectively. Hyperproducers generated by metabolic engineering of biosurfactant producers are highly desired to overcome this obstacle. ...
Department of Energy (DOE) and the National Science Foundation (NSF) to "develop a roadmap of necessary advances in basic science and engineering capabilities, including knowledge, tools and skills" to accelerate the advanced manufacturing of chemicals using biological systems. Thirteen committee members with expertise in synthetic biology, metabolic ...
Despite these impediments and although microalgae are not superior to higher plants in terms of photosynthetic efficiency and productivity, microalgal cultures remain one of the most attractive sources of feed, food and next-generation biofuels since microalgae can be grown in saline or seawater on nonarable lands, can use fertilizers with an almost 100% efficiency, are able to attain much higher ...
This problem has been addressed by metabolic engineering, which has extended endogenous insect cell N-glycosylation pathways and enabled glycoprotein sialylation by baculovirus/insect cell systems. ...
We report pyruvate formation in Escherichia coli strain ALS929 containing mutations in the aceEF, pfl, poxB, pps, and ldhA genes which encode, respectively, the pyruvate dehydrogenase complex, pyruvate formate lyase, pyruvate oxidase, phosphoenolpyruvate synthase, and lactate dehydrogenase. The glycolytic rate and pyruvate productivity were compared using glucose-, acetate-, nitrogen-, or ...
Most research strategies depend on either metabolic engineering or molecular approaches. In the present work, research compared PHA biosynthesis in two types of yeasts; Saccharomyces cerevisiae and a non-convenient Kloeckera spp. ...
The report suggested that some of these new biobased processes will result from the emerging techniques of recombinant DNA technology, metabolic engineering, functional genomics and proteomics, bioinformatics, and so on, which are rapidly outpacing advances in the more traditional and catalytic-based chemical processes. ...