Metabolic Engineering Articles & Analysis
5 articles found
One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular activities and metabolic dynamics of living systems. ...
Such models play a crucial role in better understanding the pathophysiology of diabetes, evaluating novel therapeutic strategies, and predicting the short- and long-term outcomes of different treatments on glucose metabolism and diabetes-related complications. Metabolic Disease Models Metabolic diseases encompass a wide range of conditions ...
Predicting metabolic models in the early stage of drug discovery is of great significance to improve the success rate of drug discovery. ...
This problem has been addressed by metabolic engineering, which has extended endogenous insect cell N-glycosylation pathways and enabled glycoprotein sialylation by baculovirus/insect cell systems. ...
We report pyruvate formation in Escherichia coli strain ALS929 containing mutations in the aceEF, pfl, poxB, pps, and ldhA genes which encode, respectively, the pyruvate dehydrogenase complex, pyruvate formate lyase, pyruvate oxidase, phosphoenolpyruvate synthase, and lactate dehydrogenase. The glycolytic rate and pyruvate productivity were compared using glucose-, acetate-, nitrogen-, or ...