Metabolic Study Articles & Analysis
14 articles found
This preparation contains a mixture of metabolic enzymes, including cytochrome P450s, which play a pivotal role in drug metabolism. ...
In the fast-evolving landscape of biotechnology and systems biology, understanding the dynamic processes that sustain life at a cellular level is crucial for advancing research and therapeutic applications. One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular ...
Types of ADME Testing Services To ensure comprehensive evaluation, various testing methodologies are employed, including in vitro and in vivo studies, alongside computational modeling techniques. In vitro tests often involve using cell cultures or biological fluids to assess how drugs are absorbed and metabolized. These preliminary studies can ...
By studying lipid extracts, information about the lipidome can be obtained. ...
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. ...
In addition, N15 tracing is a technique commonly used to study the nitrogen cycle. Deuterium Deuterium, also known as heavy hydrogen and H-2, is a stable isotope of hydrogen. ...
This has helped in understanding cellular trafficking, protein sorting, and localization. Metabolic labeling: SILAC has been combined with metabolic labeling techniques to study protein turnover and stability. By introducing isotopically labeled amino acids with different metabolic properties, researchers can monitor protein ...
PiT1, initially identified as retrovirus receptor, is a transmembrane protein of the sodium-phosphate co-transporter family. PiT1 also has independent functions of its role as a phosphate transporter, notably on cell proliferation, adhesion or apoptosis. These observations suggest that interactions of PiT1 with other molecular partners may impact not only the homeostasis of inorganic phosphate, ...
This modification occurs widely on proteins in cells and regulates important biological processes such as gene transcription, signal transduction, protein synthesis and metabolic reprogramming. Previous studies have shown that the level of O-GlcNAc glycosylation is abnormally increased in PDAC. ...
In previous studies, it has been reported that deubiquitinase OTU family proteins play a key role in tumor cell apoptosis and drug resistance, but its role in energy metabolism remains unclear. ...
Recently, a research paper published in Nat Commun entitled "Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides" specifically studied the enzymatic strategies and metabolic pathways used by dolphins to decompose their microbial symbiotic communities of dietary fiber. The researchers used 16S rRNA ...
In the first four patients, the implant was safely attached throughout the study period and in most patients the corneal thickness decreases without pathological thinning,” she said. Visual acuity also improved in two patients even though that was not a primary goal of the study. The gold standard for treating corneal endothelial failure is human donor ...
Organophosphorus pesticide exposure may alter amphibian embryonic development and the reproductive success of autochthonous species. In the present study, embryos of the common toad Rhinella arenarum were employed to assess developmental alterations and to study polyamine metabolism, which is essential to normal growth, as a possible target ...
The ratio of Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Osteoprotegerin (OPG) has become an important marker to assess the status of systemic bone metabolism and has been shown to be dysregulated in AS patients. Combined Low-Dose Radon- and Hyperthermia Therapy (LDRnHT) causes pain reduction in patients with AS and induces the cytokine transforming growth ...