Neurodegenerative Disorder Articles & Analysis: This-Year
8 articles found
Dysregulation of ubiquitination is a hallmark of numerous human diseases, including many cancers, neurodegenerative disorders like Parkinson's and Alzheimer's, and autoimmune conditions. ...
This allows for the identification of novel acetylated proteins and provides quantitative insights into how acetylation patterns change in disease states, such as cancer, metabolic disorders, and neurodegenerative conditions. This technology is indispensable for discovering new diagnostic biomarkers and therapeutic targets, pushing the boundaries of our ...
This innovative approach has led to breakthroughs in understanding complex brain functions, neurodegenerative disorders, and psychiatric conditions. The Role of AAVs in Optogenetics Adeno-associated viruses are particularly well-suited for optogenetics due to their ability to provide stable gene expression in non-dividing cells, such as neurons. ...
As a result, PROTACs have emerged as a promising strategy in various fields such as oncology, neurodegenerative disorders, and autoimmune diseases. The Role of Discovery Services Discovery services play a critical role in the early stages of PROTAC development. ...
APIs for Parkinson's Disease: Continuing the Fight Against Neurodegeneration Parkinson's disease, a progressive neurodegenerative disorder, manifests through symptoms such as bradykinesia, muscle rigidity, and tremors. ...
Disease Modeling: Custom knockout cell lines can mimic specific diseases by disabling genes associated with particular disorders. This modeling can be invaluable for studying the pathophysiology of diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. The combination of these approaches allows for a comprehensive view of the molecular environment within and around exosomes. ...
An imbalance of NAD⁺ and NADH levels can lead to metabolic disorders and oxidative stress. Biosynthesis and Signaling: Beyond redox reactions, NAD⁺ also acts as a substrate for enzymes like sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, which regulate DNA repair, aging, and cell signaling. ...