Neurodegenerative Disorder Articles & Analysis
20 articles found
Dysregulation of ubiquitination is a hallmark of numerous human diseases, including many cancers, neurodegenerative disorders like Parkinson's and Alzheimer's, and autoimmune conditions. ...
This allows for the identification of novel acetylated proteins and provides quantitative insights into how acetylation patterns change in disease states, such as cancer, metabolic disorders, and neurodegenerative conditions. This technology is indispensable for discovering new diagnostic biomarkers and therapeutic targets, pushing the boundaries of our ...
This innovative approach has led to breakthroughs in understanding complex brain functions, neurodegenerative disorders, and psychiatric conditions. The Role of AAVs in Optogenetics Adeno-associated viruses are particularly well-suited for optogenetics due to their ability to provide stable gene expression in non-dividing cells, such as neurons. ...
As a result, PROTACs have emerged as a promising strategy in various fields such as oncology, neurodegenerative disorders, and autoimmune diseases. The Role of Discovery Services Discovery services play a critical role in the early stages of PROTAC development. ...
APIs for Parkinson's Disease: Continuing the Fight Against Neurodegeneration Parkinson's disease, a progressive neurodegenerative disorder, manifests through symptoms such as bradykinesia, muscle rigidity, and tremors. ...
Disease Modeling: Custom knockout cell lines can mimic specific diseases by disabling genes associated with particular disorders. This modeling can be invaluable for studying the pathophysiology of diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. The combination of these approaches allows for a comprehensive view of the molecular environment within and around exosomes. ...
An imbalance of NAD⁺ and NADH levels can lead to metabolic disorders and oxidative stress. Biosynthesis and Signaling: Beyond redox reactions, NAD⁺ also acts as a substrate for enzymes like sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, which regulate DNA repair, aging, and cell signaling. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA ...
This characteristic is being explored in the treatment of conditions such as osteoarthritis, cardiovascular diseases, and neurodegenerative disorders. Immunomodulation: These cells exhibit immunomodulatory properties, which means they can influence the immune response. ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to neural stem cells ...
Additionally, membrane scaffold proteins are implicated in various diseases, including cancer and neurodegenerative disorders. Understanding the role of these proteins in disease progression can lead to the development of targeted therapies. ...
These advancements have opened up new avenues for the discovery of more effective and safer therapeutic agents, offering hope for the treatment of a wide range of diseases, from cancer and neurodegenerative disorders to infectious diseases and rare genetic conditions. ...
For instance, altered metabolite profiles have been associated with cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Uncover Drug Targets: Metabolomics aids in the identification of potential therapeutic targets by highlighting specific metabolites or metabolic pathways that are dysregulated in diseases. ...
Understanding Complex Diseases: Many diseases, such as cancer and neurodegenerative disorders, are multifaceted and involve intricate molecular pathways. ...
These findings hold potential implications for Parkinson’s disease (PD), a neurodegenerative disorder that involves the PPN. The study’s insights into the distinct roles of glutamatergic neurons in the PPN highlight potential avenues for deep brain stimulation in PD treatment. ...
The precise modification of peptides through bioconjugation provides opportunities for the development of peptide-based therapeutics targeting cancer, neurodegenerative disorders, or metabolic diseases. Peptide RNA conjugation: It refers to the process of attaching a therapeutic peptide molecule to an RNA molecule to create a novel therapeutic entity. ...
Additionally, ox bile extract powder is used in the formulation of gallbladder medications to treat gallstones and biliary tract disorders. The unique properties of ox bile extract powder help to dissolve and prevent the formation of gallstones, providing relief to patients suffering from these conditions. ...
“After years of research, we believe that A-I can provide the path to relief for millions of people suffering from Neurodegeneration such as Alzheimer’s, Parkinson’s and other neuro-brain disorders and mental diseases.” At the Dubai conference Dr. Newton will be showcasing ni20, a dynamic spinout company from his Oxford team’s research, which is ...
Kannalife is developing proprietary CBD and CBD-like molecules for neurodegenerative disorders, including chemotherapy-induced peripheral neuropathy (CIPN). ...