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Oncology Articles & Analysis
150 articles found
Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. ...
One such approach involves the repositioning, or repurposing, of drugs already FDA approved in either non-oncology disease states and/or approved in a limited number of tumor types. ...
Significance in Research The creation of SV40-immortalized human ovarian epithelial cells represents a breakthrough for oncology and reproductive biology. These cells provide a consistent and reproducible model for studying various aspects of ovarian biology, including cellular differentiation, hormonal responses, and the mechanisms underlying tumor formation. ...
Cancer Treatment: By delivering genes that can induce cancer cell death or enhance the immune response against tumors, adenoviruses are part of innovative approaches in oncology. The Adenovirus Production Process Producing adenoviruses involves a series of carefully controlled steps to ensure the final product’s safety and effectiveness. ...
Enhanced Tumor Targeting (Passive Accumulation) In oncology, PEGylated drugs benefit from the Enhanced Permeability and Retention (EPR) effect, where leaky tumor vasculature allows selective accumulation of macromolecules. ...
Since then, the BCL2 protein has become a key target in oncology and molecular biology. Functions and Roles in the Body Proteins encoded by the BCL2 gene family function primarily at the mitochondrial membrane, where they regulate the release of cytochrome c—a crucial step in the apoptotic process. ...
From recombinant chemokines used in research to targeted therapies in oncology and neurology, their potential is vast yet complex. While challenges remain in harnessing their full therapeutic potential, continued research and innovation promise to unlock new strategies in precision ...
Modern research focuses on developing novel mechanisms of action, combination therapies, and antimicrobial stewardship programs to preserve the efficacy of these vital medicines. Oncology and High-Potency APIs (HPAPIs) represent cutting-edge pharmaceutical development, characterized by extreme potency at minute concentrations. These specialized compounds often target cancer by ...
In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. ...
Alfa Cytology's development services for FAP-targeted therapeutics mark an essential breakthrough in precision oncology. Through their complete design and development solutions program, the company has become an essential partner to cancer research organizations worldwide. ...
Such therapies have shown promise in clinical trials, particularly in oncology, where tumors may express multiple surface antigens. By directing the immune system to attack cancer cells in a more coordinated manner, these novel approaches provide new avenues for treatment, particularly for patients with refractory or relapsed diseases. ...
These cells are of significant interest in oncology due to their potential to provide vital information about the tumor’s characteristics and behavior. ...
Applications in Medicine Histological image analysis has a broad range of applications in medicine, particularly in oncology, where it aids in the diagnosis and grading of tumors. It enables pathologists to assess tumor behavior, predict patient outcomes, and tailor treatment plans accordingly. ...
Alfa Cytology, which stands at the forefront of oncology service provision in New York United States, has announced its sophisticated antibody-drug conjugates(ADCs) development services for cancer. ...
Future Directions in ADC Development The field of ADC development is rapidly evolving, with ongoing research focused on improving therapeutic outcomes and expanding their application beyond oncology. Innovations such as next-generation linkers, novel cytotoxic agents, and combination therapies are being explored to enhance the effectiveness of ADCs. ...
As a result, PROTACs have emerged as a promising strategy in various fields such as oncology, neurodegenerative disorders, and autoimmune diseases. The Role of Discovery Services Discovery services play a critical role in the early stages of PROTAC development. ...
Applications Across Biomedical Research The adaptability of organoid technology makes it essential for multiple biomedical research fields: · Oncology – Patient-derived tumor organoids serve as a powerful system for developing personalized cancer treatments and evaluating drug effectiveness. ...
Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. ...
The idea of synthetic lethality has transformed the approach to personalized medicine in oncology. Researchers are actively identifying and characterizing other synthetic lethal interactions that could lead to innovative treatments for various cancers. ...
Immuno-oncology is an innovative field that utilizes the body’s immune system to combat cancer. ...