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Oral Administration Articles & Analysis

25 articles found

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Absorption The bioavailability of protein drugs such as antibodies is extremely low after oral administration. The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by ...

ByCreative Proteomics


An Overview of Isotopes

An Overview of Isotopes

The most reliable way to detect HP is to use this non-invasive 13C-UBT method, which can infer H. pylori in the stomach by detecting the 13C/12C isotope ratio in the exhaled gas after oral administration of 13C-urea. Drug Metabolism Study The study of drug metabolism in the body is a very critical process for the development of new drugs, and the elements of ...

ByBOC Sciences


Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

Most other AMPs are too toxic for systemic administration but can be safely used topically on the skin for superficial cuts and abrasions. ...

ByBOC Sciences


Development of mRNA-Directed Delivery - LNP Delivery System

Development of mRNA-Directed Delivery - LNP Delivery System

Various administration routes have been used to achieve site-specific delivery of LNP, including oral administration, inhalation, and local injection (intramuscular, intratumoral, and intracerebral injection). 1) Oral administration is a widely used, convenient, and well-established route of ...

ByBOC Sciences


G Protein-Coupled Receptors targeted by antibodies raised against three dimensional epitopes

G Protein-Coupled Receptors targeted by antibodies raised against three dimensional epitopes

Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...

ByImmune Biosolutions Inc.


Applications of Liposomal Drug Delivery System Technology

Applications of Liposomal Drug Delivery System Technology

The protective effect of loaded molecules makes liposomes a good candidate carrier for oral vaccines.Oral administrationIt has been reported that the main factors affecting the stability of oral drugs include bile, pH values and pancreatic enzymes in the gastrointestinal environment. Microemulsions are prepared by using liposomes as suspensions or solubilizers ...

ByCD Formulation


Huateng Pharma Supplies Ensitrelvir Intermeidates Against COVID-19

Huateng Pharma Supplies Ensitrelvir Intermeidates Against COVID-19

In cells, low nanomolar to sub-micromolar doses of Ensitrelvir suppress viral growth. In hamsters, oral treatment of Ensitrelvir showed excellent pharmacokinetic qualities and hastened recovery from acute SARS-CoV-2 infection. ...

ByHunan Huateng Pharmaceutical Co. Ltd.


The Importance of Moderate Supplementation of Intestinal Lactase

The Importance of Moderate Supplementation of Intestinal Lactase

Directly supplement lactase and produce low-lactose products. Oral administration of exogenous lactase and hydrolysis of lactose by lactase to produce low-lactose or lactose-free dairy products to assist the digestion and absorption of lactose are currently widely concerned research hotspots. ...

ByCreative Enzymes


Some Basic Facts about Active Pharmaceutical Ingredient Excipients for Drug Discovery

Some Basic Facts about Active Pharmaceutical Ingredient Excipients for Drug Discovery

Excipients can be classified by source, function, route of administration, and the like. By Source They can be divided into natural, semi-natural and fully synthetic excipients. By Function They can be divided into solvents, propellants, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, ...

ByCD Formulation


New Study Findings about Glycoprotein PTGDS

New Study Findings about Glycoprotein PTGDS

PTGDS, as a bifunctional protein, catalyzes the production and transport of lipophilic substances by PGD2. Oral administration of AT56, a selective inhibitor of PTGDS, competitively inhibited PTGDS activity (Km=14 μM). ...

ByCD BioGlyco.


Rani developing technology for oral delivery of injectable biologics

Rani developing technology for oral delivery of injectable biologics

(NASDAQ:RANI) is developing a disruptive technology to solve the problem of converting biologic injectable drugs, including antibodies, peptides and proteins, into oral therapies with its RaniPill that bypasses destruction in the stomach to deliver its payload to the vascular intestinal wall in the GI tract. ...

ByRani Therapeutics


Techniques to Enhance Drug Solubility

Techniques to Enhance Drug Solubility

Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability ...

ByCD Formulation


The Reality and Future of Peptide Drugs

The Reality and Future of Peptide Drugs

Compared to chemical drugs, peptides are physicochemically unstable, susceptible to oxidation and hydrolysis, prone to agglomeration, have a shorter half-life, have a faster clearance rate, do not readily cross cell membranes, and most cannot be taken orally. Therefore, it is necessary to carry out rational design of peptide drugs according to their advantages and disadvantages. ...

ByCreative Peptides


Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

On week 4, oral administration of KBL382 significantly suppressed the development of dermatitis scores compared to DFE+PBS mice. ...

ByKoBioLabs


IMCAS Americas 2019 Shined in Sunny Cartagena

IMCAS Americas 2019 Shined in Sunny Cartagena

The plan is to run one or two more trials and then approach the US Food and Drug Administration in 2020.” Taking on psoriasis and eczema. “We have recently conducted promising animal studies looking at topical administration of cyclosporine with our technology in psoriasis and eczema. Due to side effects seen with oral ...

ByDyve Biosciences


Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis

Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis

Administration of L. fermentum KBL375 significantly decreased dermatitis score, ear and dorsal thickness, and serum immunoglobulin E level in AD-induced mice. ...

ByKoBioLabs


Novel nanoplatform for oral delivery of anti–cancer biomacromolecules

Novel nanoplatform for oral delivery of anti–cancer biomacromolecules

Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. ...

ByInderscience Publishers


Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol

Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol

Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation (2–6 Gy), significantly protected cellular DNA in various tissues of mice, as evident from alkaline comet assay. ...

ByInderscience Publishers


Mathematical modelling of nanoparticle biodistribution: extrapolation among intravenous, oral and pulmonary administration routes

Mathematical modelling of nanoparticle biodistribution: extrapolation among intravenous, oral and pulmonary administration routes

In this study, a physiological-based mathematical model was developed to describe and compare the absorption, distribution, metabolism, and elimination (ADME) of nanoparticles after intravenous (IV), oral, and pulmonary exposure. The development of the model was based on physiological principles, compartmental analysis, and mathematical modelling. ...

ByInderscience Publishers


Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol

Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol

Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation ...

ByInderscience Publishers

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