Oral Administration Articles & Analysis
25 articles found
Absorption The bioavailability of protein drugs such as antibodies is extremely low after oral administration. The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by ...
The most reliable way to detect HP is to use this non-invasive 13C-UBT method, which can infer H. pylori in the stomach by detecting the 13C/12C isotope ratio in the exhaled gas after oral administration of 13C-urea. Drug Metabolism Study The study of drug metabolism in the body is a very critical process for the development of new drugs, and the elements of ...
Most other AMPs are too toxic for systemic administration but can be safely used topically on the skin for superficial cuts and abrasions. ...
Various administration routes have been used to achieve site-specific delivery of LNP, including oral administration, inhalation, and local injection (intramuscular, intratumoral, and intracerebral injection). 1) Oral administration is a widely used, convenient, and well-established route of ...
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...
The protective effect of loaded molecules makes liposomes a good candidate carrier for oral vaccines.Oral administrationIt has been reported that the main factors affecting the stability of oral drugs include bile, pH values and pancreatic enzymes in the gastrointestinal environment. Microemulsions are prepared by using liposomes as suspensions or solubilizers ...
In cells, low nanomolar to sub-micromolar doses of Ensitrelvir suppress viral growth. In hamsters, oral treatment of Ensitrelvir showed excellent pharmacokinetic qualities and hastened recovery from acute SARS-CoV-2 infection. ...
Directly supplement lactase and produce low-lactose products. Oral administration of exogenous lactase and hydrolysis of lactose by lactase to produce low-lactose or lactose-free dairy products to assist the digestion and absorption of lactose are currently widely concerned research hotspots. ...
Excipients can be classified by source, function, route of administration, and the like. By Source They can be divided into natural, semi-natural and fully synthetic excipients. By Function They can be divided into solvents, propellants, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, ...
PTGDS, as a bifunctional protein, catalyzes the production and transport of lipophilic substances by PGD2. Oral administration of AT56, a selective inhibitor of PTGDS, competitively inhibited PTGDS activity (Km=14 μM). ...
(NASDAQ:RANI) is developing a disruptive technology to solve the problem of converting biologic injectable drugs, including antibodies, peptides and proteins, into oral therapies with its RaniPill that bypasses destruction in the stomach to deliver its payload to the vascular intestinal wall in the GI tract. ...
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability ...
Compared to chemical drugs, peptides are physicochemically unstable, susceptible to oxidation and hydrolysis, prone to agglomeration, have a shorter half-life, have a faster clearance rate, do not readily cross cell membranes, and most cannot be taken orally. Therefore, it is necessary to carry out rational design of peptide drugs according to their advantages and disadvantages. ...
On week 4, oral administration of KBL382 significantly suppressed the development of dermatitis scores compared to DFE+PBS mice. ...
The plan is to run one or two more trials and then approach the US Food and Drug Administration in 2020.” Taking on psoriasis and eczema. “We have recently conducted promising animal studies looking at topical administration of cyclosporine with our technology in psoriasis and eczema. Due to side effects seen with oral ...
Administration of L. fermentum KBL375 significantly decreased dermatitis score, ear and dorsal thickness, and serum immunoglobulin E level in AD-induced mice. ...
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. ...
Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation (2–6 Gy), significantly protected cellular DNA in various tissues of mice, as evident from alkaline comet assay. ...
In this study, a physiological-based mathematical model was developed to describe and compare the absorption, distribution, metabolism, and elimination (ADME) of nanoparticles after intravenous (IV), oral, and pulmonary exposure. The development of the model was based on physiological principles, compartmental analysis, and mathematical modelling. ...
Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation ...