Postmortem Articles & Analysis
5 articles found
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
Until then, tauopathy was mainly characterized by clinical diagnosis and postmortem neuropathology. Combined with their previous work, these findings of cryo-electron microscopy suggest a new, layered approach and use this to classify tau filament folding in tauopathy. ...
To better understand the mechanisms underlying these two categories of ALS, Dangond et al. performed transcriptomics analyses using postmortem tissue samples from spinal cord grey matter of ALS patients. ...
ByPercayAI
The mortuary holds approximately 60 bodies (including bariatric facilities) and also has 3 postmortem tables, since post-mortem examinations are sometimes requested by hospital doctors to provide more information about an illness or the cause of death, or to further medical research. ...