Squamous Cell Carcinoma Articles & Analysis
10 articles found
Bispecific antibodies have two antigen-binding arms, one of which binds to the target antigen and the other to the labeled antigen on the effector cells. The latter can activate the effector cells to target and kill tumor cells. ...
In NSCLC, high Trop-2 expression was observed in 64% of adenocarcinomas and 75% of squamous cell carcinomas (SqCCs). In addition to its function of regulating normal fetal development, Trop-2 is also an intracellular calcium signal transducer, a key component of cell adhesion in human tissues, and plays an important role in ...
CADM1 is involved in mediating interactions between cancer cells and immune cells, such as T cells and natural killer (NK) cells. ...
The antibody can be released to partially target and attach to HER2 on cancer cells, and upon entering the cancer cells, release chemotherapeutic drugs to kill the cancer cells as well as nearby cells. ...
Moreover, LFQ is commonly used in biomarker detection of other diseases and tumors, such as Vps35 for Parkinson's disease, SOAT1 for hepatocellular carcinoma, GOT2 for prostate cancer, A1AT for bladder cancer. Stable isotope labeling with amino acids in cell culture (SILAC) Stable isotope labeling with amino acids in cell culture is an in vivo ...
Methods: We identified 275 patients who underwent surgical resection for pathologic stage I-II lung adenocarcinoma or squamous cell carcinoma from 2009 to 2019 in our institution’s prospective surgical database. ...
Abstract The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state. To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of ...
Glycosylation regulates a range of physiopathological processes, including cell-cell adhesion, cell-matrix interactions, epithelial-mesenchymal transition, tumor proliferation, invasion, metastasis, and angiogenesis. ...
Christian Hense, chief operating officer of Universal Dx, said that the method's workflow begins by collecting about 4ml of plasma from 8ml to 10ml of a patient's blood sample for cell-free DNA (cfDNA) extraction. After Universal Dx performs a series of processing steps to enrich for targets of interest, Hense said that the team then uses methylation-sensitive restriction enzyme ...
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...