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Therapeutic Candidate Articles & Analysis

10 articles found

Innovative Preclinical Alfa Cytology alfaCAR-T Solutions: Revolutionizing the CAR-T Development Platform

Innovative Preclinical Alfa Cytology alfaCAR-T Solutions: Revolutionizing the CAR-T Development Platform

By fostering an environment of innovation and collaboration, Alfa Cytology not only advances its therapeutic candidates but also contributes to the broader field of cancer research. ...

ByAlfa Cytology


Single-Domain Antibody Production: A Comprehensive Overview

Single-Domain Antibody Production: A Comprehensive Overview

This stability makes them suitable candidates for therapeutic use and allows for diverse storage conditions. ...

ByCreative Biogene


Advancements in Breast Cancer Research: The Role of Tumor Models and Customized ADCs Development Services

Advancements in Breast Cancer Research: The Role of Tumor Models and Customized ADCs Development Services

These advancements not only enhance our understanding of the disease but also pave the way for more targeted therapeutic solutions. Tumor models for breast cancer, which include both in vivo and in vitro systems, are crucial for studying the complexities of tumor biology and testing potential treatments. ...

ByAlfa Cytology


AI and Multiplex Cloning Redefine Aantibody Discovery

AI and Multiplex Cloning Redefine Aantibody Discovery

This not only integrates the advantages of various methods but also accelerates the early discovery stage of therapeutic development. In situations where computer simulation analysis and AI-driven antibody discovery run parallel to in vivo methods, we are expected to predict and prioritize potential antibody candidates. ...

ByMtoZ Biolabs


Painting the Picture of Recursion

Painting the Picture of Recursion

We tend to be so specialized that it’s difficult to fund a team bringing the necessary expertise together to push potential therapeutics along the pathway. I knew it would be incredibly rewarding to see these two lead a company and carry out their vision. ...

ByRecursion


Discovery of Bispecific Antibodies and Immune Checkpoint Inhibitors That Kill Glioblastoma Cells and Melanoma Cells, and Block the Metastasis of Malignant Melanoma Cells to the Lung by Over 90%

Discovery of Bispecific Antibodies and Immune Checkpoint Inhibitors That Kill Glioblastoma Cells and Melanoma Cells, and Block the Metastasis of Malignant Melanoma Cells to the Lung by Over 90%

Antibodies that target ICPI such as PD-1, PD-L1 and CTLA4 have been generated which have therapeutic efficacy in NSCLC and other tumors. Unfortunately, only a minority of patients respond to these therapies and the responses are often not durable. ...

ByOcean Biomedical


Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus

Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus

Results will inform protocol design of Phase 1/2 clinical trial of Company's lead HSV-2 therapeutic vaccine candidate WOBURN, Mass. and OXFORD, England, Aug. 15, 2022 /PRNewswire/ -- Rational Vaccines, a company focused on revolutionizing the treatment and prevention of herpes to eradicate the disease, today announced the launch of a clinical trial designed to ...

ByRational Vaccines, Inc.


Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment

Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment

Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. ...

ByInsilico Medicine


Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma

Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma

This study describes the functional kinomic landscape of Ras/p53 mutant chemically-induced squamous cell carcinoma in both the baseline unperturbed state and following DNA damage and nominates candidate therapeutic targets, including the Nek4 kinase, for further development. ...

BySEngine Precision Medicine


Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

Here we outline how machine learning, advances in viral immunology, and high-throughput measurements can enable engineering of a new generation of de-immunized capsids beyond the antigenic landscape of natural AAVs, towards expanding the therapeutic reach of gene therapy. Introduction Recently approved AAV-based therapeutics and numerous ...

ByDyno Therapeutics

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