Tissue Specific Articles & Analysis
46 articles found
These experiments are essential for dissecting the cross-talk between mineralization control and TGF-β superfamily pathways in tissue development and disease. 4. Antibody Development and ELISA Standards Purified recombinant MGP serves as an antigen for monoclonal or polyclonal antibody production. ...
The potential to tailor VLPs for specific immunological demands positions them as a powerful tool for future vaccine innovations. ...
The Power of Optogenetics Optogenetics enables researchers to control specific neurons using light, offering insights into neural circuits’ dynamics and behaviors. ...
Each chemokine binds to a corresponding G-protein-coupled receptor (GPCR), enabling specific cellular responses depending on the receptor-ligand pairing. ...
By employing various staining techniques, histologists can highlight specific cell types and extracellular matrix components, enabling a clearer visualization of tissue architecture. ...
Research in the field of pulmonary biology often requires detailed analysis of lung tissues. One of the optimal methods for studying lung structures and functions in mice is the use of C57 mouse models, specifically through the preparation of frozen sections. ...
Understanding Radioactive Drug Conjugates Radioactive drug conjugates are engineered to deliver radiation directly to cancer cells while sparing healthy tissues. This specificity is achieved by linking a radioactive isotope to a monoclonal antibody or small molecule that targets specific cancer antigens. ...
They develop from progenitor cells, which researchers obtain either from embryonic tissues or pluripotent stem cells (PSCs). Through traditional embryonic tissue reaggregation experiments, researchers developed methods demonstrating that progenitor cell aggregates can differentiate and self-assemble into structures resembling early organ formation processes. ...
By introducing synthetic mRNA into the body, researchers can instruct cells to produce specific proteins that play critical roles in immune responses or disease treatment. ...
Nanobodies can be engineered to specifically target tissues or cells of interest by conjugating them to therapeutic agents. ...
Alternative splicing plays a significant role in various biological processes, including tissue-specific functions, cell signaling, and the regulation of gene expression. ...
Dendrimers can be designed with specific structures and functionalities that allow precise control of their properties, such as size, shape, solubility, and stability. Dendrimers can also be designed with targeting ligands that allow them to selectively deliver drugs or imaging agents to specific cells or tissues, perfecting their effectiveness ...
Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body. In this article, we will explore different types of nanoparticle development that are revolutionizing drug delivery systems. ...
Incorporating recombinase technology into AAVs develops unique rAAV particles that can target specific DNA sequences. Substantial strides have been made in constructing rAAV particles to transport the recombinase components to the target cells. Studies have demonstrated impressive preclinical results, allowing for precise modification in specific organs or cell ...
Targeted liposomes Coating the surface of liposomes with hydrophilic polymers such as polyethylene glycol is an easy way to achieve targeted drug delivery, which tends to minimize subsequent uptake by the reticuloendothelial system and therefore Circulation time is longer for passive accumulation in cancer tissue. In addition, various active substances can be coupled to the ...
PROTAC antibody conjugates formed by coupling antibodies and PROTAC molecules can specifically degrade target proteins in specific cells, achieving the selectivity of PROTAC technology at the cellular or tissue level. ...
Cytokine Receptor-Targeting Chimeras (KineTACs) Due to limitations in lysosome delivery targeting chimeras, such as low modularity, high development difficulty, poor practicality, and limited tissue specificity, Professor James A. Wells' team at the University of California, San Francisco (UCSF) developed KineTACs. ...
Alternative splicing plays a significant role in various biological processes, including tissue-specific functions, cell signaling, and the regulation of gene expression. ...
Although TMB shows potential as a biomarker for immunotherapy in solid tumors, consensus on the optimal TMB threshold for specific tumor types remains elusive. Refining the TMB threshold could significantly enhance therapeutic approaches for certain refractory tumors. ...
Organoids are defined as three-dimensional structures grown from stem cells and composed of organ-specific cell types that can self-organize to recapitulate key and functional features of tissues in a dish. ...