Tumor Dna Articles & Analysis

1 articles found

Selection against puma gene expression in myc-driven b-cell lymphomagenesis

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eµ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that 75% of Eµ-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately ...

Sep. 1, 2008

ByAmerican Society for Microbiology (ASM)

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