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Tumor Microenvironment Articles & Analysis
39 articles found
This modification system plays a crucial role in cellular biological processes such as tumor metabolism and immune regulation while also shaping the tumor microenvironment through control of translation efficiency and mitochondrial function along with tRNA fragment generation. ...
One of the most significant applications lies in cancer immunotherapy. Tumors often manipulate chemokine pathways to evade immune surveillance. By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. For ...
The complex nature of cancer treatment highlights the critical requirement for therapies that show both effectiveness and precise targeting of tumor biology. The conventional treatment approaches fail to accurately target cancer cells, which results in numerous adverse effects while diminishing treatment success. ...
During in vitro incubation researchers can administer interferon-γ-inducible protein 10 (IP10) inside platelets. Within the tumor microenvironment elevated levels of thrombin activate the IP10-platelet complex which releases its drug payload leading to substantial anti-tumor results. The IP10-loaded platelets targeted and inhibited ...
The firm develops monoclonal antibodies that target tumor-specific antigens through the services. This method shows potential for better patient response rates while simultaneously enabling the detection of tumor progression and resistance mechanisms. ...
The monoclonal antibody is designed to bind specifically to cancer cells, ensuring that the toxic drug is delivered directly to the tumor, thereby minimizing damage to healthy cells. This targeted approach enhances the therapeutic index of the drug, resulting in improved efficacy and reduced side effects compared to conventional chemotherapy. ...
Their roles span across embryonic development, wound healing, angiogenesis, and tumor progression. Measuring growth factor levels in biological samples is crucial for understanding how cells communicate and adapt to physiological changes or pathological insults. ...
Researchers use these models because they retain many of the biological properties of the original tumors, thus providing insights into the cancer’s behavior. The establishment of cell lines involves extracting cancer cells from a tumor biopsy, followed by their growth in a nutrient-rich medium under sterile conditions. ...
These innovative methods enable the identification and generation of highly specific antibodies that can deftly navigate the complex tumor microenvironment of bladder cancer. By harnessing a deep understanding of immunology and molecular biology, Alfa Cytology strives to supply more possibilities for preclinical therapeutic regimens. ...
These models allow researchers to mimic the tumor microenvironment, providing insights into the behavior of cancer cells, their interactions with surrounding tissues, and their responses to various therapeutic agents. ...
Passive targeting exploits the enhanced permeation and retention (EPR) effect, a phenomenon observed in certain pathological tissues, such as tumors, characterized by leaky vasculature and poor lymphatic drainage. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Moreover, the versatility of these probes allows for multiplexing with other markers, providing researchers with a comprehensive analysis of cellular interactions and dynamics within the tumor microenvironment. This comprehensive approach is essential for gaining insights into the mechanisms of CAR-T cell therapy and optimizing treatment strategies. ...
Brain tumors can be broadly categorized into primary and secondary (or metastatic) tumors. Primary tumors originate in the brain1, while secondary tumors spread from other body parts. ...
While it was first discovered in gliomas (a type of brain tumor), TNC protein is present in a variety of tissues, especially during embryonic development and tissue remodeling after injury. ...
Dr. Kate Sasser from Tempus led a discussion on the potential of antibody-drug conjugates (ADCs), their challenges in targeting tumor antigens, and the future of cancer treatment with Dr. Daniel Johnson, Dr. Funda Meric-Bernstam, and Dr. Kellogg Parsons. The oncology field is rapidly advancing with the development of antibody-drug conjugates (ADCs), offering new hope for ...
ByTempus
Alfa Cytology has announced tumor models customization service for pancreatic cancer research. ...
Notably, both cancer cells and host cells employ inducible CD73 expression, alongside other adenosinergic molecules, to establish and perpetuate an immunosuppressive microenvironment within the tumor. This orchestrated strategy affects various dimensions of the immune response. ...
Reduced CADM1 expression may lead to the dampening of immune cell responses, limiting their ability to identify and attack cancer cells effectively. Immunosuppressive Microenvironment: Tumors can create an immunosuppressive microenvironment that hinders immune responses. CADM1 may be involved in modulating the immune cell composition within the ...
It is involved in the formation and development of the tumor microenvironment (TME) and plays an important role in regulating immune responses. ...