MagQu LLC USA products

Amyloid β (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer`s disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. One of the most common isoforms is Aβ1-42.¹,² Aβ1-42 Protein Control Solution is used as a standard control for “MagQu” Amyloid β 1-42 IMR Reagent (MF-AB2-0060). The antibody conjugated on the surface of Fe3O4 magnetic particles (~ 50 nm) could bind with Aβ1-42 protein and form clusters. With the increase of cluster, the signal of ac susceptibility ( χac ) will decrease in the applied ac magnetic field. That is the principle of Immuno Magnetic Reduction (IMR). By measuring the reduction of χac, we can quantify the Aβ1-42 protein in the sample easily and accurately.³

Use Tau protein IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.). The reagent is used to quantitatively measure Tau protein in human fluid specimen, such as plasma. Tau protein is a microtubule-associated protein and is abundant in nervous system. Tau protein can maintain the structure of neuron cells and support the transport of substance. When tau proteins become defective, It will result in the self-assembly of tangles in brain and increased some neurodegenerative diseasesincluding Alzheimer’s disease (AD)?Pick`s disease?Parkinson`s disease (PD)?Progressive supranuclear palsy(PSP) and Corticobasal degeneration (CBD).

The magnetic immunoassay analyzer (Model: XacPro-S) created by MagQu Co., Ltd. is used to measure the change in the ac magnetic susceptibility of a sample over time. If a sample is mixed with our IMR reagent, the concentration of bio-molecules can be measured in correlation with the change in the ac magnetic susceptibility of the mixture. XacPro-S can be applied to molecular detection not only for research, but also for clinical diagnosis and field trials. Potential target bio-molecules include proteins, viruses, nucleic acids , bacteria, and even small molecular compounds.