Model CL-AB2-020T - Amyloid ß1-42 IMR Protein Control Solution-M

Amyloid β (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer`s disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. One of the most common isoforms is Aβ1-42.¹,² Aβ1-42 Protein Control Solution is used as a standard control for “MagQu” Amyloid β 1-42 IMR Reagent (MF-AB2-0060). The antibody conjugated on the surface of Fe3O4 magnetic particles (~ 50 nm) could bind with Aβ1-42 protein and form clusters. With the increase of cluster, the signal of ac susceptibility ( χac ) will decrease in the applied ac magnetic field. That is the principle of Immuno Magnetic Reduction (IMR). By measuring the reduction of χac, we can quantify the Aβ1-42 protein in the sample easily and accurately.³