Spectral Medical Inc.

Spectral’s vision is to provide a personalized approach that will enable vastly improve outcomes for patients with septic shock by combining a targeted diagnostic test and therapy. It is widely known that endotoxin is a trigger of sepsis. Spectral has conducted a Phase III clinical trial for its lead product, PMX (Toraymyxin™ PMX-20R), for the treatment of patients with septic shock and endotoxemia (measured by the Company’s Endotoxin Activity Assay (EAA™)). PMX is a therapeutic hemoperfusion device that removes circulating endotoxin from the bloodstream. The EUPHRATES pivotal trial, (Evaluating Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock) showed that PMX, when applied to septic shock patients with a baseline value of endoxotin acitivity (EA) between 0.6 and 0.9, reduces mortality and improves organ dysfunction. EAA™ and PMX are both Health Canada licensed and commercially available in Canada.