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Methylmalonic acidemia (MMA) and propionic acidemia (PA) are rare intoxication-type inborn errors of metabolism that are characterized by acute metabolic decompensations, acidosis and hyperammonemia leading to severe organ damage, seizures, developmental deficits, and premature death. In the United States, about 1 in 70,000 newborns is diagnosed with MMA, and 1 in 240,000 is diagnosed with PA. ...
Methanol causes optic neuritis and severe metabolic acidosis. Ethyl alcohol administered intravenously is the antidote. The intravenous administration of sodium bicarbonate is useful in controlling acidosis. Inhalation: Remove to fresh air. If symptoms develop, seek immediate medical attention. ...
More acid urine (lower pH values) is found in case of an increased protein metabolism, high fever, serious diarrhoea and metabolic acidosis (serious form of diabetes mellitus). Alkalinity (increased pH value) may be noted in urinary tract infections, respiratory or metabolic alka-losis.- Early detection of diabetes mellitus- ...