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Phenotype Articles & Analysis
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Combined with nanotechnology, "smart" drugs can actively target tumors by binding to corresponding receptors on tumor cells through interactions with phenotype-specific ligands conjugated to the delivery vehicle. Additionally, binding to certain receptors can trigger internalization and help avoid the development of resistance mechanisms. ...
Hit identification and optimization Creative Diagnostics provides comprehensive support for drug screening using virtual, biochemical, biophysical, cellular and phenotyping platforms. The company offers phenotyping, biochemical and cellular assays for microbial and cellular growth inhibition in recombinant human cells or primary cells, bacteria, viruses, yeast ...
Asthma remains a complex and multifactorial disease, with airway hyperresponsiveness to methacholine being a hallmark feature. A recent study by Rojas-Ruiz et al (2025) utilizes SCIREQ’s innovative physioLens (ex vivo) and flexiVent (in vivo) platforms to shed light on the interplay between lung tissue compliance and methacholine response, offering new insights into the mechanisms ...
The rise of antibiotic-resistant bacteria has driven renewed interest in alternative treatments, including phage therapy. A recent study by Yang, F., et al (2024) explores the potential of bacteriophage therapy for treating multi-drug resistant Mycobacterium tuberculosis (Mtb) infections using humanized mouse models. This study highlights the efficacy of phage DS6A in reducing Mtb load ...
Its state-of-the-art laboratory equipment and techniques allow scientists to perform 3D imaging and phenotyping of cell populations throughout the depth of the tissue for biological research. ...
Ayla Annac, InvivoSciences: InvivoSciences (IVS) is a leading developer of proprietary, award-winning platform technologies that creates human 3D cell/tissue culture models and their automated phenotype analyzers for drug discovery and precision medicine development. ...
(IVS) is a leading developer of proprietary human 3D cell/tissue culture models for highly-predictive, multi-parameter phenotypic assays both in pharmacology safety & discovery screening and in personalized and regenerative medicine. ...
” They then used conditional logistical regression by estimating the association of metabolite patterns with prostate cancer risk. Metabolic Phenotyping Can Bolster Fight Against PC From a metabolic research stance, PC is very different from other cancers because prostatic tissue shows high metabolic activity. ...
Dr. Ali Tinazli is the CEO of lifespin.health and has 15+ years in Fortune 100 corporate strategy and entrepreneurship (SONY, HP). Obesity rates continue to climb alongside a $254.9 billion global weight loss products and services market. Supplements, smartphone weight loss apps, diet plans and exercise programs are widely available to consumers, yet the World Obesity Federation projects that 1 ...
The Company’s proprietary technology uniquely enables the recovery of specific live cell subpopulations without altering the cells by exploiting biophysical differences in cell phenotypes. This label-free approach improves the quality of the cell samples recovered, providing more accurate representation of human disease, and enabling their maintenance and viability for ...
4D Path applies universal physics, biology and mathematical principles to identify tumor-specific phenotypic and genotypic fingerprints. Its system runs on modern cloud components that enable dynamic scaling and batch processing, allowing 4D to optimize run times and deliver rapid results. ...
Its platform is commercially available worldwide now to identify tumor-specific phenotypic and genotypic fingerprints that can inform treatment selection as well as stratify patients for novel targeted therapies without the need for a training dataset or human intervention. ...
The variation reflects cellular characteristics, or phenotype, and thus RNA analysis gives a more accurate view of the state cells in comparison to DNA analysis. ...
The study titled, “Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes,” assessed the relationship between cardiac filling pressures (a commonly used surrogate to assess blood volume) and total blood volume (TBV) measurement using Daxor’s BVA-100 blood test between sexes and left ventricular ejection fraction (LVEF), key clinical determinants ...
Background Differentiation arrest resulting from aberrant methylation represents a key pathogenic and phenotypic feature of MDS. Hypomethylating agents (HMA) can reverse epigenetic dysregulation, but single agents fail to control the disease in approximately 50% of patients, many of whom progress to AML and carry a dismal prognosis. ...
However, a number of retrospective studies confirm a high degree of similarity between the phenotype and genotype of a PDO and an original patient tumor, showing that if a drug worked on the PDO, it was 90 percent likely to work on the patient. ...
Bacterial/fungal/viral/parasitic resistance studies: the metabolic state of bacteria is associated with a range of genetic and phenotypic resistance mechanisms. Thus, metabolomics is used to determine the relationship between antimicrobial resistance (AMR) mechanisms and microbial metabolism. 2. ...
Title: ES009, a LILRB2-specific blocking antibody, reprograms myeloid cells into pro-inflammation phenotype and potentiates T cell activation Abstract No.: 1062 LILRB2 is predominantly expressed in myeloid lineage cells. ...
After airborne infection with Mycobacterium Tuberculosis, the new model system aims to show the disease-specific phenotype of “frustrated” phagocytosis, air-blood barrier damage, activated lymph node tissue and granuloma formation and maintenance. ...
Altoida, Inc., the precision neurology company pioneering non-invasive brain health measurement and neurological disease diagnostics with AI and augmented reality (AR), today announced that management will be presenting at the upcoming conferences: BioFuture Panel Title: New Diagnostics: Revolutionizing Care in Alzheimer’s Date/Time: Wednesday, Nov. 9, 10:30 – 11:30 am ET Location: ...