MedChemExpress LLC (MCE)

MedChemExpress - Model Picroside II - 39012-20-9

Picroside II is an antioxidant with oral activity that can reduce the production of ROS and protect the blood-brain barrier (BBB) after CI/R injury, offering neuroprotective effects. Picroside II has antioxidant, immune-regulating, antiviral properties, and inhibits apoptosis. Picroside II alleviates the inflammatory response in sepsis by suppressing the activation of the NLRP3 inflammasome and NF-κB pathways[1][2][3][4][5].

Picroside II

MCE China：Picroside II

Brand：MedChemExpress (MCE)

Cat. No.HY-N0408

CAS：39012-20-9

Purity：99.91%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Picroside II is an antioxidant with oral activity that can reduce the production of ROS and protect the blood-brain barrier (BBB) after CI/R injury, offering neuroprotective effects. Picroside II has antioxidant, immune-regulating, antiviral properties, and inhibits apoptosis. Picroside II alleviates the inflammatory response in sepsis by suppressing the activation of the NLRP3 inflammasome and NF-κB pathways.

In Vitro：Picroside II (5-20 μM, 24 h) upregulates the expression of the bcl-2 gene in primary rat liver cells[1]. Picroside II (0-300 μM, 24 h) inhibits the growth of HepG2 cells[2]. Picroside II (10 μM, 20 h) reduces the transcription of genes involved in fatty acid uptake and synthesis in HepG2 cells[2].

In Vivo：Picroside II (0-20 mg/kg, i.g., given in two doses) protects liver cells from damage and prevents apoptosis[1]. Picroside II (20 mg/kg, intravenous injection, given in four doses) inhibits the activation of NLRP3 inflammasome and NF-κB pathway in mice, reducing the inflammatory response in sepsis and enhancing immune function[3]. Picroside II (20 mg/kg, intraperitoneal injection, a single dose) protects the blood-brain barrier by inhibiting oxidative signaling pathways in a rat model of ischemia-reperfusion injury[4]. Picroside II (5-20 mg/kg, i.g., once a day for seven days) has anti-lipid peroxidation effects and protects against mitochondrial damage in mice with liver injury[5].

References：

[1]. Hua Gao, et al. Inhibitory effect of picroside II on hepatocyte apoptosis. Acta Pharmacol Sin. 2005 Jun;26(6):729-36. [Content Brief]

[2]. Hiteshi Dhami-Shah, et al. Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis. Clin Mol Hepatol. 2018 Mar;24(1):77-87. [Content Brief]

[3]. Huang Y, et al. Picroside II protects against sepsis via suppressing inflammation in mice. Am J Transl Res. 2016 Dec 15;8(12):5519-5531. eCollection 2016. [Content Brief]

[4]. Zhai L, et al. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS One. 2017 Apr 7;12(4):e0174414. [Content Brief]

[5]. Hua Gao, et al. Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. World J Gastroenterol. 2005 Jun 28;11(24):3671-4. [Content Brief]

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