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Blood Brain Barrier Equipment & Supplies
195 equipment items found
by:Vaxxinit based inDallas, TEXAS (USA)
Targets toxic forms of aggregated α-synuclein in the brain to fight Parkinson’s and other synucleinopathies, such as dementia with Lewy Body (“DLB”) and multiple system atrophy (“MSA”). The first part of a Phase 1 trial in healthy volunteers has shown UB-312 to be well tolerated, with no significant safety findings, and immunogenic, with a high responder rate ...
Manufactured by:Diverse Biotech Inc based inDoylestown, PENNSYLVANIA (USA)
Specific Advantages of Conjugate Platform: Potential Step increase in efficacy. Rapid absorption and distribution. Increased lipophilicity (cross blood–brain barrier). Effective to >10x the current standard of care. Potential to lower dose of current highly-toxic therapeutic agents in the market ...
Manufactured by:OPKO Health, Inc. based inMiami, FLORIDA (USA)
Our reversible PEGylation technology is a novel technique for creating extended release therapeutics. In reversible PEGylation, a conjugate is formed through a proprietary bi-functional hydrolyzable linker, between a drug that contains a primary peptide and a polyethylene glycol (PEG) chain. Once the conjugate enters the bloodstream the linker hydrolyzes at physiological pH and body temperature, ...
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism oflevodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system effect.http://www.creative-peptides.com/product/carbidopa-item-10-101-135-25.html ...
Manufactured by:MitoImmune Therapeutics Inc. based inGangnam-gu, SOUTH KOREA
The blood-brain barrier (BBB) penetrating technology is essential to develop drugs for neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease, which have high unmet medical needs. MitoImmune has developed BIM Technology, a central nervous system target technology, and is conducting R&D for the treatment of neurodegenerative disease. BIM ...
Manufactured by:Reglagene Holding, Inc. based inTucson, ARIZONA (USA)
RGNXXXX is a potent, orally administered, blood-brain barrier penetrant therapy that is being optimized for the treatment of anti-infectivity and neuro-inflammation, such as acute COVID-19 and neuro-inflammatory diseases, respectfully. ...
Manufactured by:Reglagene Holding, Inc. based inTucson, ARIZONA (USA)
RGN3118 is a potent, orally administered, blood-brain barrier penetrant therapy that has been optimized for the treatment of high-grade gliomas, such as glioblastoma as well as brain metastases from breast, lung, and melanoma cancers. ...
Manufactured by:Lauren Sciences LLC based inNew York City, NEW YORK (USA)
V-Smart Platform, breakthrough innovation, winning trifecta for brain delivery, enables non-invasive, triple-targeted CNS delivery of non-BBB penetrant therapeutic agents (nucleic acids, antibodies, biologics, small molecules, ...
Manufactured by:ScienCell Research Laboratories based inCarlsbad, CALIFORNIA (USA)
Brain microvascular endothelial cells (BMEC), the major component of the blood-brain barrier, limit the passage of soluble and cellular substances from the blood into the brain. BMEC have unique features to distinguish themselves from those of peripheral endothelial cells, such as 1) intercellular tight junctions that display high electrical resistance and slow paracellular flux, 2) the absence ...
by:Kurve Therapeutics, Inc. based inLynnwood, WASHINGTON (USA)
Researchers and scientists have spent the last 25 years trying and failing to develop effective treatments for brain diseases. The majority of the traditional treatments methods available can’t bypass the blood brain barrier, leaving the majority of the medication behind in the nasal cavity, sinuses, or GI tract. Other methods also can produce a number of undesirable side effects. ...
by:TAE Life Sciences (TLS) based inFoothill Ranch, CALIFORNIA (USA)
TAE Life Sciences is committed to developing a portfolio of novel targeted boron drugs to expand the application of BNCT to other cancer types and to provide even better outcomes for indications historically treated with Boronophenylalanine (BPA), a boron delivery ...
Manufactured by:Reglagene Holding, Inc. based inTucson, ARIZONA (USA)
Only 4 of the 217 FDA-approved oncology medicines are indicated for life-threatening brain cancers. The most recent approval was in 2009, but this medicine did not extend life expectancy. Patients deserve better therapies that extend life and improve quality of life. The Reglagene team is developing a first-in-class blood–brain barrier (BBB) penetrant medicine that effectively fights brain ...
Manufactured by:Kirkstall Ltd. based inYork, UNITED KINGDOM
The QV600 chamber has been designed for surface cultures, such as skin, respiratory epithelium or whole corneas. Additionally, the use of transwells to create a double cavity chamber is ideal for the study of membranes and barrier models. The QV600 provides a constant medium surface, positioned to allow the membrane on commercial inserts to sit at this height and provide cell cultures with a ...
Manufactured by:Emergent BioSolutions Inc. based inGaithersburg, MARYLAND (USA)
Raxibacumab is indicated for the treatment of adult and pediatric patients with inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs. Raxibacumab is also indicated for prophylaxis of inhalational anthrax when alternative therapies are not available or are not ...
Manufactured by:Lys Therapeutics based inCAEN, FRANCE
Glunomab / Glunozumab®: a monoclonal antibody counteracting the strong toxicity triggered by the interaction of an endogenous protease, tissue plasminogen activator (tPA) with NMDA receptors ...
Manufactured by:ClearPoint Neuro, Inc. based inIrvine, CALIFORNIA (USA)
The SmartFlow MR Compatible Ventricular Cannula has received 510(k) clearance from the FDA for use in the US for the aspiration of CSF, or injection of the chemotherapy drug Cytarabine into the ventricle. It has also been CE marked for use in Europe for the delivery of approved fluids into the brain or aspiration of CSF. It’s being utilized in approved clinical and preclinical studies for ...
Manufactured by:Pfizer Inc. based in, NEW YORK (USA)
ACCUPRIL® is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5 ...
Manufactured by:Neurovision Medical Products based inVentura, CALIFORNIA (USA)
DryTouch integrates monopolar stimulation with a Frazier suction instrument for brain mapping, minimally invasive thyroidectomies, and spinal ...
Manufactured by:Virpax Pharmaceuticals based inBerwyn, PENNSYLVANIA (USA)
Endogenous peptides with analgesic potential include endorphins via binding to the mu receptor, dynorphins via the kappa receptor and enkephalins via the delta receptor. Kappa and delta opioid agonists have been shown to provide analgesic benefit while sparing mu agonist toxicity1. Preclinical data supports analgesia from enkephalin without significant opioid tolerance or drug liking. Typically, ...
Manufactured by:ALZET Osmotic Pumps based inCupertino, CALIFORNIA (USA)
Many agents do not cross the blood-brain barrier sufficiently to evaluate their effects on the brain without delivering them locally. Cerebral injection is one local delivery method, but it can be challenging to deliver an effective dose in a physiologically-compatible volume. In addition, the agent may not remain in the target location long enough to see an effect. For many compounds, local ...