MedChemExpress - Model Scopolamine hydrochloride -55-16-3

Scopolamine hydrochloride is a non-selective and high affinity (≤1 nM) muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. Scopolamine readily passes the blood brain barrier. Scopolamine also reversibly inhibits 5-HT3 receptor-responses with an IC50 of 2.09 μM[1]. Scopolamine induces Alzheimer's disease-like pathology through alteration of cholinergic system[2].

Scopolamine hydrochloride

MCE China：Scopolamine hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-B2065

CAS：55-16-3

Synonyms：(-)-Scopolamine hydrochloride; Hyoscine hydrochloride

Storage：Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Scopolamine hydrochloride is a non-selective and high affinity (≤1 nM) muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. Scopolamine readily passes the blood brain barrier. Scopolamine also reversibly inhibits 5-HT3 receptor-responses with an IC50 of 2.09 μM. Scopolamine induces Alzheimer's disease-like pathology through alteration of cholinergic system.

In Vitro：Scopolamine blocks nicotinic acetylcholine receptors (IC50=928 μM) and increases the expression of α7 nACh receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17±0.24 (Ki=6.76 μM). Concentration-dependent competition of fluorescently labeled form of granisetron (G-FL) with Scopolamine gives an average pKi of 5.31±0.09 (Ki=4.90 μM).Scopolamine blocks muscarinic receptors and induces a cognitive deficit[1]. Scopolamine (0.1-3 mM; for 24 hours) induces cytotoxicity, ROS generation and apoptosis of SH-SY5Y cells[2].

In Vivo：Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain[3].

IC50 & Target：5-HT3 Receptor 2.09 μM (IC50)

References：

[1]. Martin Lochner, et al. The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology. 2016 Sep;108:220-8. [Content Brief]

[2]. Nicha Puangmalai, et al. Neuroprotection of N-benzylcinnamide on scopolamine-induced cholinergic dysfunction in human SH-SY5Y neuroblastoma cells. Neural Regen Res. 2017 Sep;12(9):1492-1498. [Content Brief]

[3]. Barbara Budzynska, et al. Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Psychopharmacology (Berl). 2015 Mar;232(5):931-42. [Content Brief]

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MedChemExpress - Model Scopolamine hydrochloride -55-16-3

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Scopolamine hydrochloride