MedChemExpress LLC (MCE)

MedChemExpress - Model Protectin D1 - 660430-03-5

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].

Protectin D1

MCE China：Protectin D1

Brand：MedChemExpress (MCE)

Cat. No.HY-130413

CAS：660430-03-5

Synonyms：Neuroprotectin D1; NPD1

Purity：99.10%

Storage：Solution, -20°C, 2 years

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders.

In Vitro：Protectin D1 (1 μM, 24h) exerts cardioprotective effects in primary neonatal rat cardiomyocytes by upregulating miRNA-210 expression and activating the PI3K/AKT signaling pathway[3].

In Vivo：Protectin D1 (0.5, 1 μM/kg/day, i.p., once daily for 3 days) improves cardiac function and reduced infarct size in I/R-induced AMI rat model by inhibiting oxidative stress and inflammation[3]. Protectin D1 (0.08 mg/kg, i.p., single dose) exerts anti-inflammatory effects in CLP-induced sepsis rat model by reducing ROS concentration, inhibiting NALP3 inflammasome activation, and decreasing pro-inflammatory cytokine levels[4].

IC50 & Target：Human Endogenous Metabolite IL-1β

References：

[1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823. [Content Brief]

[2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859. [Content Brief]

[3]. Zhang P, et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J Cardiovasc Transl Res. 2024 Apr;17(2):376-387. [Content Brief]

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