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Disease Modeling Equipment & Supplies
99 equipment items found
Manufactured by:Ncardia Services B.V. based inLeiden, NETHERLANDS
The discovery that transformed biological research. In 2007, Shinya Yamanaka and Kazutoshi Takahashi were able to reprogram human somatic cells into pluripotent stem cells by inducing the expression of four embryonic transcription factors. The resultant cells were called human induced pluripotent stem cells (iPSC). iPSCs have unlimited proliferation capacity and can be differentiated into nearly ...
Manufactured by:Systasy Bioscience GmbH based inMunich, GERMANY
The DiseasePROFILER uses a subset of top-performing sensors identified in the PathwayPROFILER assay and enables simple, robust, and cost-effective screening of compound effects in human disease models. ...
Manufactured by:vivoVerse Inc. based inAustin, TEXAS (USA)
Our large-scale microfluidic chip for high-throughput screening of C. elegans disease models at high-content, is published in Nature Communications (DOI 10.1038/ncomms13023). The platform enables high-resolution imaging and analysis of ~4,000 C. elegans from 96 different populations in approximately 15 minutes. ...
Manufactured by:GENFIT based inLoos, FRANCE
This program consists in a repositioning of Nitazoxanide, or NTZ*, that is being investigated for the treatment of fibrosis in pre-clinical disease models. NTZ is currently being evaluated in an investigator-initiated proof-of-concept clinical trial for the potential treatment of NASH-induced significant liver fibrosis. For more information, go to clinical ...
Manufactured by:Jiangsu Xietong Pharmaceutical Bio-engineering Co., Ltd. based inNanjing City, CHINA
Rodent Diet with 60% Calories from Fat (ref. D12492) and its adjusted formula are widely used in the establishment of obesity and type 2 diabetes and other disease models in rats, and its advantage lies in its stable modeling cycle and high modeling ...
Manufactured by:Jiangsu Xietong Pharmaceutical Bio-engineering Co., Ltd. based inNanjing City, CHINA
Rodent Diet with 45% Calories from Fat (ref. D12451) and its adjusted formula are widely used in the establishment of obesity and type 2 diabetes and other disease models in rats, and its advantage lies in its stable modeling cycle and high modeling ...
Manufactured by:Trailhead Biosystems Inc. based inBeachwood, OHIO (USA)
We will make our endothelial cells available for drug discovery, organ or tissue printing, high throughput or high content screening, toxicity and efficacy testing, and human disease modeling. ...
by:bit.bio based inCambridge, UNITED KINGDOM
Introducing highly-defined, consistent and reliable human muscle cells for research, disease modelling and high throughput screening across areas such as muscle, neuromuscular, and associated metabolic disorders. ioSkeletal Myocytes have been reprogrammed from human induced pluripotent stem cells (iPSCs) using our precise reprogramming technology: ...
Manufactured by:Stem Pharm, Inc based inMadison, WISCONSIN (USA)
Stem Pharm’s advanced neural organoid models uniquely contain microglia and provide new opportunities to investigate CNS disease modeling, drug discovery, and toxicology applications. ...
Manufactured by:InvivoSciences, Inc. (IVS) based inMadison, WISCONSIN (USA)
InvivoSciences (IVS) combines its human micro tissue technology and phenotypic assay platform with the systems biology approach to achieve rare disease modeling for its drug discovery. Our strip tissues are perfect for modeling muscle and connective tissue in micro-well plates. Since many rare diseases affect heart muscle and ...
Manufactured by:Auris Medical AG based inBasel, SWITZERLAND
The OligoPhore™ / SemaPhore™ technology has been extensively and successfully tested with various siRNA and mRNA sequences in numerous disease models in mice. For the development of our first proprietary drug product, AM-401 (OligoPhore™ siRNA targeting KRAS), we have initiated a program of IND-enabling ...
by:Reaction Biology Corp. based inMalvern, PENNSYLVANIA (USA)
The Biomarker Analysis tool identifies genes or genetic alterations which are indicative for the efficacy of a drug and which may serve as predictive biomarkers in disease models and patient ...
Manufactured by:Ncardia Services B.V. based inLeiden, NETHERLANDS
Astrocytes are essential players in neurodegenerative disease progression providing a valuable tool for drug discovery and disease modeling. Human iPSC-derived astrocytes generated with our standardized process express key identity markers and support co-culture with human iPSC-derived neurons. Our team can manufacture astrocytes at scale ...
Manufactured by:Hemogenyx Pharmaceuticals plc based inLondon, UNITED KINGDOM
Originally developed for in-house testing, the company’s Advanced peripheral blood Hematopoietic Chimera (“ApbHC”) is a novel type of humanised mouse that presents several advantages over existing mouse models. It has applications for disease modelling and drug development, and potentially for ...
Manufactured by:InSphero AG based inSchlieren, SWITZERLAND
The 3D InSight™ Steatosis Model is an advanced human disease model that enables you to screen compounds and investigate disease pathophysiology using a physiologically relevant human liver microtissue that recapitulates the first stage of non-alcoholic fatty liver disease: accumulation of lipids in ...
Manufactured by:ROKIT Healthcare based inGeumcheon-gu, SOUTH KOREA
It is widely applicable to the fields of bioengineering and medicine, from in vitro applications in novel product screening, disease modeling, and animal alternative experimentation to in vivo applications in tissue transplantation and ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
MPTP hydrochloride is a brain penetrant dopamine neurotoxin. MPTP hydrochloride can be used to induces Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. MPTP hydrochloride has been verified by MCE with professional biological ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
MPT0G211 can penetrate the blood-brain barrier. MPT0G211 ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model. MPT0G211 has anti-metastatic and neuroprotective effects. Anticancer ...