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Disease Modeling Articles & Analysis
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Diabetes mellitus, a chronic condition characterized by elevated blood sugar levels, affects millions worldwide and poses serious health risks including cardiovascular disease, kidney failure, and nerve damage. As the prevalence of diabetes continues to rise, there is an urgent need for advanced research models that can accurately simulate the ...
Several disease models of Zika virus infection have been established in mice and non-human primates (NHPs) and used for diagnostic, therapeutic and preclinical evaluation of Zika virus vaccines. As Zika virus is associated with severe neurological disease and in an effort to prevent and protect against this virus, Creative Diagnostics provides ...
Chronic Obstructive Pulmonary Disease (COPD) is a global health burden characterized by persistent airflow limitation and progressive lung damage. Despite extensive research, translating findings from bench to bedside remains a challenge. Precision Cut Lung Slices (PCLS) have emerged as a versatile tool in COPD research, offering unique advantages for understanding disease mechanisms and ...
Ace Therapeutics is proud to announce the launch of its cardiovascular disease model development services, aiming to empower researchers and pharmaceutical companies with advanced tools and models to accelerate the study of cardiovascular diseases and drug discovery. ...
The incidence of landscape fires has been rising globally, leading to increased exposure to landscape fire smoke (LFS) among millions of people. The inhalation of particulate matter (PM) from LFS is associated with adverse respiratory and cardiovascular outcomes. However, the mechanisms by which LFS impacts these functions remain inadequately understood. This blog focuses on a new ...
Following with the announcement of developing small molecule drug for glaucoma, Ace Therapeutics recently unveiled disease model customization services to accelerate further the preclinical research on gastroenterology (GI) and hepatology. ...
Depression is commonly seen in neurodegenerative and neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and autism spectrum disorders. ...
Cell-based therapy and tissue engineering have long held the promise of transforming healthcare by enabling the regeneration of damaged tissues and the development of advanced disease models. However, the lack of bioinks suitable for clinical applications has been a significant barrier to progress. ...
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By providing customized organs-on-chips, Alfa Chemistry enables researchers to explore new horizons and gain innovative insights into complex diseases, drug interactions and personalized medicine. Organ-on-chip technology is increasingly utilized in various areas such as toxicity assessment, disease modeling, drug evaluation, and more. ...
While on January 20th 2014, InvivoSciences and BMG LABTECH will be presenting a workshop tutorial at Society for Laboratory Automation and Screening (SLAS) in San Diego, CA These Workshops will highlight applications of pluripotent cells and engineered tissues in drug discovery, including disease model generation as well as personalized and regenerative ...
https://www.termis.org/wc2018/ On September 7th, CSO speaks about monogenic disease modeling using NuHeart™ technology during TERM for heart, blood vessel & lung session. 99-O-5: Personalized micro-3D human heart tissues for orphan drug development Tetsuro Wakatsuki,Neil Daily,Pinar Kemanli, Michael Greenberg,Jennifer Strande InvivoSciences, Inc. ...
Application of induced pluripotent technology allows to fabricate tissues in diseased states, e.g., hereditary cardiac diseases, cardiac fibrosis, cancer and orphan diseases. ...
In particular, overweight or obese men are at a heightened risk for earlier progression and development of metastatic disease, more adverse effects from treatment and a higher likelihood of fatality. ...
VG801 is based on the Company’s novel adeno-associated virus (AAV) technology platforms, enabling the efficient expression of large genes in retinal photoreceptors after intravitreal injection. The data from a Stargardt disease model will be presented in a poster session at the European Society of Gene & Cell Therapy (ESGCT) Congress, Edinburgh, October ...
“Low efficacy is often not because the drug fails to hit its target, but is more often a consequence of a molecularly naïve approach to a heterogenous and complex disease. The Cellworks platform uses computational biosimulation to model signaling pathways, master regulators, hallmark behaviors of cancer, and drug interactions with each patient’s ...
” A leader in contract research, development and manufacturing of human-induced pluripotent stem cell-based solutions (iPSC), Ncardia’s capabilities include bio-reactor-based scalable manufacturing of iPSC derived cells, assay development, disease modeling, and cell-based screening. “We are thrilled to welcome Kiniciti as our strategic ...
In recent years, CRISPR technology has significantly promoted the innovation of gene therapy for blood diseases, tumors, genetic diseases, and other diseases, which has become a powerful tool in the field of scientific research. ...
Cellworks Personalized Therapy Biosimulation The Cellworks Platform biosimulates how a patient's personalized genomic disease model will respond to therapies prior to treatment and can also identify novel drug combinations for treatment-refractory patients. ...
” Cellworks Therapy Biosimulation The Cellworks Platform biosimulates how a patient's personalized genomic disease model will respond to therapies prior to treatment and can also identify novel drug combinations for treatment-refractory patients. ...
“We look forward to combining our product development expertise with the capabilities of AFRIMS in chikungunya epidemiology and field studies, and of our academic partners in infectious disease modeling and efficacy trial design, to find ways to address chikungunya disease, a public health threat for which no vaccine or treatment ...