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CHOvolution - CHO-K1 based Cell Expression Platforms
FromCELONIC Group
An extremely productive and stable CHO-based expression system for biopharmaceuticals. CHOvolution® is a CHO-K1 based expression platform that can be used for a broad range of applications, from non-GMP R&D testing to GMP development and commercial market supply, with a support system to help throughout every step of development. Besides offering cell line development services, Celonic is selling and outlicensing the system to other service providers and drug developers.
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cell line development
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- Antibodies of different isotypes (e.g. IgG1, IgG2, IgG4)
- Bispecific and single chain antibodies
- Enzymes, growth factors and hormones
- CHO-K1 host cell line (non genetically modified CHO)
- For high titer bioproduction of recombinant proteins and monoclonal antibodies (up to 8 g/L)
- High genetic stability and physical robustness allows scalable process from 250 mL to 1000 L single use bioreactors
- Proven track record: therapeutics developed with CHOvolution® technology have been approved for clinical trials in the EU, US and Asia
- Free of royalties and milestone payments
- Ideal for R&D development to cGMP commercial production
- Easy to implement with industry-compliant user protocol (from gene to lead clone).