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GENLISA - Human TNF-Alpha (Tumor Necrosis Factor Alpha) Elisa
Tumor necrosis factor alpha (TNF ±) is a multifunctional cytokine secreted primarily by macrophages, natural killer (NK) cells, and lymphocytes.The main function of TNF Alpha is to regulate the immune cells. It has the ability to induce a fever, speed up cell death, create inflammation etc. It stimulates the acute phase response on the liver, which can lead to a growing amount of C-reactive protein in this organ. Furthermore, TNF functions to bring about insulin resistance, which prevents blood sugar levels from properly decreasing.When concentration levels of TNF are increased, it leads to inflammation signs such as swelling, pain, and redness. Abnormally high levels of TNF have also been linked to a wasting syndrome that causes the body to drastically lose weight at an unhealthy rate. This is often common in cancer patients.Therefore, many inflammatory diseases have been treated by using a TNF inhibitor.
This prevents TNF Alpha from functioning properly, reducing the signs of inflammation.TNF alpha and Covid-19:TNF-alpha is important in nearly all acute inflammatory reactions and has been identified in the blood and tissues of COVID-19 patients. Antibodies against TNF-alpha have been used for more than 20 years in severe cases of autoimmune inflammatory disease. There are currently 10 FDA-approved and four off-label indications for anti-TNF therapy indicating the validity in targeting this inflammatory factor. The GENLISA ELISA kits are used for assessing the specific biomarker in samples analytes which may be serum, plasma and cell culture supernatant as validated with the kit. The kit employs a sandwich ELISA technique which leads to a higher specificity and increased sensitivity compared to conventional competitive ELISA kits which employ only one antibody. Double antibodies are used in this kit.