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multimmuneModel ENKASTIM-iv - In vivo Stimulation of Natural Killer (NK) Cells

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In vivo application of ENKASTIM-iv, an Hsp70-based GMP-grade synthetic peptide comprising 14 amino acids (14mer), results in a specific activation of NK cells which acquire the capacity to recognise and kill membrane Hsp70-positive tumors and metastases.

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Status: Proof of principle studies in a pre-clinical mouse colon tumor model have demonstrated that three repeated intravenous injections of ENKASTIM (TKD/IL-2) resulted in a 60% reduction in the tumor size.