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PhenoSys - Model qOMR - Optomotor Response System (OMR)
The optomotor response (OMR) is a reflex used to assess visual function. The PhenoSys qOMR (quantitative optomotor response) is a unique system that automatically measures the OMR with minimal experimenter effort. It uses a virtual stimulation cylinder that continuously aligns with the animal´s head position. Based on real-time head tracking, quantitative OMR measurements run fully automatically and objectively. This is a PhenoSys Collaboration product brought to market together with its developer, Dr. Friedrich Kretschmer.
Hardware features
- Calibrated 4 screen environment for presenting the virtual stimulation cylinder
- Elevated central platform for placing the unrestrained animal
- Top and bottom mirrors to create the illusion of infinite depth for optimized stimulation
- IR-camera with adjustable IR-illumination for automated head tracking
- IR-illumination for automated head tracking.
Software features
- Video-based real-time tracking of head movement is used for both:
1. Continuous automated position-adjustment of the virtual cylinder to the animal´s head position.
2. Evaluation of head movement synchronous to the stimulation for a quantitative measure of the optomotor response. This analysis is fully automated. - Batch run option with multiple stimulation protocols.
- Example for real-time tracking:
qOMR video with visible stimulus
- Investigation of various aspects of vision in mice and other rodents:
- Visual acuity
- Contrast sensitivity
- Spectral sensitivity
- Temporal sensitivity
2. Characterisation or preclinical testing in relevant disease models, for example:
- Glaucoma
- Retinal degeneration
- Diabetes
- Aging
3. Examination of axonal regeneration.
- Simple, robust, and non-invasive test to examine vision in rodents
- Fully automated measurement and analysis: no manual positioning of the stimulus, no specially trained experimenter required, time and cost effective, and unbiased
- As a reflex, optomotor response measurements do not require animal training
- Freely behaving animals, no surgery, no fixation
- Flexible, user-friendly experimental design and data handling.
The PhenoSys qOMR is a PhenoSys Collaboration product. These products are brought to market together with the scientists who developed them.
qOMR is a joint product of Dr. Friedrich Kretschmer and PhenoSys.
qOMR is based on his publications: