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SLE Monitor Test Kit
SLE Monitor combines three widely used biomarkers of SLE disease activity with the DxTerity IFN-1 test. The SLE Monitor Test is undergoing evaluation as a "from home" test. Check back for information about enrolling in the ELEVATE clinical study.
The panel contains 4 biomarkers (Anti-dsDNA, Complement C3, Complement C4, and IFN-1)1,2,3,4,5. This Test is currently available as Research Use Only and is not for use in diagnostic procedures.
Anti-dsDNA
High titers of antibodies to double-stranded DNA (anti-dsDNA) are usually seen in people who have SLE, often significantly increased during or just prior to a flare-up, and generally associated with ongoing inflammation and damage to the kidneys.4 A very low level of anti-dsDNA is considered negative but does not exclude a diagnosis of lupus. Anti-dsDNA tests can be repeated at regular intervals to monitor progression of the disease. Anti-dsDNA is quantified using a ELISA immunoassay method.
Complement C3 and C4
Complements C3 and/or C4 decreased levels are associated with an increased risk of developing an autoimmune disease and are typically depressed in SLE and especially in cases with lupus nephritis.1,2,5 Normalization of complement C3 and C4 has been shown to correlate with disease improvements in SLE. The complement test can be repeated at regular intervals to monitor progression of the disease. C3 C4 is measure through ELISA immunoassay method
IFN-1
The IFN-1 test measures the relative expression of mRNAs associated with Type 1 Interferon activity. The mRNA results are used to calculate the IFN-1 score, which is evaluated against an established threshold to determine if a patient is IFN-1 high or IFN-1 normal (low)3.
SLE Monitor Test uses quantitative ELISA immunoassay for measuring anti-dsDNA, complement C3, and complement C4. The DxTerity IFN-1 test uses Chemical Ligation Dependent Probe Amplification (CLPA) followed by Capillary Electrophoresis analysis.