High Throughput Antibody Characterization Services
Antibody based therapeutics constitutes a major portion of drug discovery research today. However, antibodies as drugs or diagnostic agents present significant analytical challenges because antibodies are large, complex, and heterogeneous molecules. Surface Plasmon Resonance (SPR) is a powerful analytical technology that is well suited for analyzing and characterizing antibodies. SPR can be used to measure the antibody-antigen binding kinetics, perform epitope binning and epitope mapping. The latter may be used to identify antibody pairs for developing high-precision ELISA or multiplex assays.. Aviva Systems Biology is combining decades of antibody and ELISA research expertise with the innovative Carterra LSA to provide high throughput antibody characterization services.
- High throughput: Kinetically screen and rank up to 1,152 mAbs, 384 clones at one time in parallel
- Low sample usage: Only < 200µl of each interactant required
- Ease-of-use: Simple sample layouts prevent the need for complex plate maps and multiple aliquots of each reagent
- Rapid data analysis: Powerful software tools enable large data-sets to be rapidly fitted and visualized and automatically validated against several data quality parameters
- Detailed data mining: Interrogate mAb panels via interactive on-rate, off-rate, affinity and iso-affinity plots
- Data integration: Combine binning and kinetics screening data for un-paralleled mAb evaluation