creative bioarray - In vitro Skin Models

Advances had been made towards the use of in vitro human skin equivalents/models for dermal drug and cosmetic product testing. In vitro Skin Models (Human Skin Equivalent, FTSK, HSE) used under defined test conditions offer several advantages: i) since most models are composed of primary human cells, inter-species extrapolation is avoided; ii) in contrast to human skin specimens, repeated application of formulations can be performed for at least several weeks; iii) work with the ready to use tissue models do not require advanced knowledge of cell culture techniques; iv) the employment of in vitro skin models lead to the reduction of laboratory animal use in regulatory toxicology as well as in preclinical studies.