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Disease Modeling Services In Usa
21 services found
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
It is indispensable and effective to use animal disease models in experimental medical research. Animal models of neurological disease provide a convenient and reliable platform for developing new therapies and drugs for such diseases. Creative Bioarray uses animal models of different ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
We mainly use the three approaches to abrogate gene function in zebrafish: stable lines carrying mutations (mutants); morpholino-based knock-down of gene function; and use of CRISPR/Cas9 gene editing to disrupt gene function in injected embryos. Many human pathological conditions from Alzheimer's disease to metabolic syndrome have been successfully modelled in ...
Manufactured by:Curi Bio based inSeattle, WASHINGTON (USA)
Curi Bio has a repository of iPSC’s for disease modeling and proprietary technologies for differentiating these cells into myoblasts and cardiomyocytes. Curi has developed in vitro 3D disease models for multiple disease phenotypes. In addition, Curi has the capability of generating new gene-edited iPSC ...
Manufactured by:Cloud-Clone Corp. based inKaty, TEXAS (USA)
The development of human disease is very complex, to itself as experimental object to in-depth study of the mechanism of disease, the accumulation of clinical experience not only in time and space are limited and many experiments on the moral are restricted. Animal models can provides the basic platform for the study of safety research of drugs, ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Creative Biogene has long-standing experience in conducting preclinical zebrafish model studies of cardiovascular disease. We offer consultancy and preclinical zebrafish models of cardiovascular disease including hypertension, arrhythmia, heart failure and atherosclerosis, etc. Similar to other animal models, ...
Manufactured by:Curi Bio based inSeattle, WASHINGTON (USA)
Curi Bio’s iPSC Repositories Available for Services. Custom Panel of Different Gender and Ethnicities. Disease Model Pairs. Patient-derived iPSC-lines. Isogenic DMD/WT Myoblasts. Isogenic DMD/WT ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Rodent disease models are widely used for a broad range of project objectives, which involve investigation of pathological process and mechanism of disease, pre-clinical tests of potential therapeutic agents, ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. It has been widely used in current ...
Manufactured by:Stem Pharm, Inc based inMadison, WISCONSIN (USA)
Stem Pharm offers a variety of services allowing for custom projects and biomaterials tailored to each customers’ ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
GLP studies are done only for development compounds being prepared for clinical trials. Creative Bioarray has conducted in vivo testing for cardiovascular disease using in vivo models for both side-effect profiling and efficacy according to your requirement. ...
Manufactured by:Mimetas B.V. based inLeiden, NETHERLANDS
Capture and understand human disease biology in vitro. The key to unlocking effective therapies for the unsolved diseases of our times is a deep understanding of human disease biology. To this end, MIMETAS aims to capture the essence of diseases in fit-for-purpose in vitro models. We are fully committed to ...
by:elminda Ltd. based inHerzliya, ISRAEL
CNS drugs exhibit the lowest approval success rates due to multiple challenges such as lack of efficacy in early and advanced stages of development, Poor target selection / engagement, poor translation from pre-clinical models and disease heterogeneity. BNA may contribute in CNS research and drug development by adding new objective endpoints, assisting in ...
Manufactured by:Nexelis based inSeattle, WASHINGTON (USA)
Custom In Vivo Models and Testing Solutions. Selecting the appropriate in vivo model for your assays is critical for the success of your preclinical research program. At Nexelis, a Q² Solutions Company, we designed and developed disease specific in vivo models alongside bespoke personalized model development ...
Manufactured by:Nexelis based inSeattle, WASHINGTON (USA)
For R&D in Immunogenicity, Immuno-Oncology, and Cell and Gene Therapy. We have exceptional in vitro bioassay development services and support for early evaluation and screening of candidate therapeutics. Our highly experienced team will facilitate in silico immunogenicity assessment with epitope prediction to in vitro immunogenicity and immuno-functionality assays. ...
Manufactured by:Ozgene Pty Ltd. based inBentley DC, AUSTRALIA
Knockout mice are animal models that have been genetically modified to delete or inactivate a specific gene. The term ‘knockout’ refers to knocking out the functionality of the target gene. These mouse models allow researchers to gain insight into how the loss of the gene affects physiology, behavior and disease development. Observing ...
by:ForeSee Medical, Inc. based inSan Diego, CALIFORNIA (USA)
The healthcare delivery model within which providers, hospitals and physicians receive payments based on patient health outcomes is understood as value-based healthcare. But what is value-based care, and what does it mean? Under value-based care parameters also known as CMS pay for performance, providers are compensated for helping patients enhance their health, reduce the ...
Manufactured by:Altis Biosystems based inDurham, NORTH CAROLINA (USA)
Accurate biological screening based on real human intestinal tissue, with a standardized workflow for reliable and reproducible data, RepliGut represents ?the next generation for in vitro testing with faster actionable data. ...
Manufactured by:InvivoSciences, Inc. (IVS) based inMadison, WISCONSIN (USA)
Human engineered tissue (EHT)-based high content analysis can be applied to drug discovery projects at their compound screening and lead optimization stage. Mass-produced human engineered tissues will recapitulate physiological functions of native tissues in micro tissues growing in 96-well plates or 384-well plates (coming soon). Patient-derived cells can also be used to fabricate engineered ...
Manufactured by:Cloud-Clone Corp. based inKaty, TEXAS (USA)
These include antisense and antigene drugs, antibody-based drugs, cytokines and protein drugs, mass screening of chemical drugs in vitro and vivo as well. It applies to the study of preclinical validity at home and ...
Manufactured by:Invicro, LLC based inNeedham, MASSACHUSETTS (USA)
Our diverse team of experts have experience in instrument engineering, signal processing, and pharmaceutical R&D, collectively resulting in a long history designing and executing imaging and pathology studies. Our scientists have performed hundreds of studies across multiple therapeutic research areas, including oncology, neuroscience, inflammation, cardiovascular, metabolic, and ...