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Drug Discovery Services In North America
106 services found
by:Molsoft LLC based inSan Diego, CALIFORNIA (USA)
Protein Modeling and Target Prioritization By applying MolSoft's acclaimed ICM modeling tools we can build three-dimensional models and fully evaluate several candidate target ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Drug Discovery and Research: Alfa Chemistry aims to support efforts to generate novel drugs by serving as a one-stop platform for the variety of services and expertise needed for drug discovery and development. We will collaborate through a combination of integrated, multidisciplinary drug ...
Manufactured by:Invicro, LLC based inNeedham, MASSACHUSETTS (USA)
Invicro has a vast range of tools that help accelerate your drug discovery and development process. Our technology platforms support key decision-making in: Early discovery and screening. Candidate selection. First-in-human translation and early development. Late stage, multi-center determination of ...
by:RTI International based in, NORTH CAROLINA (USA)
RightLeftFor more than 50 years, drug discovery and development has been one of our core research activities. We work with pharmaceutical companies and government agencies to bring new medicines to market, and to ensure the safety and efficacy of those in the marketplace. ...
Manufactured by:Molecule One sp. z o.o. based inWarszawa (Polska), POLAND
When all components of the M1 platform are deployed, along with a proprietary dataset, your entire discovery pipeline benefits. You may generate millions of compounds with high estimated synthetic accessibility, reduce reaction failure rates at the bench or automate your synthesis workflows. That enables your team to focus on more crucial discovery tasks. We can help you build a pipeline where ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
ORD Simulation Prediction: Optical rotation refers to when a beam of polarized light passes through a substance,the plane of polarized light rotates at a certain angle relative to its own direction of motion. The property of rotating polarized light that a substance has is called optical rotation. Materials with optical rotation include crystals, spin-polarized molecules and chiral molecules. For ...
by:Health Technology Innovations, Inc. based inPortland, OREGON (USA)
Cryo-EM is a powerful technology for determining high-resolution 3D structures of biological macromolecules and bound compounds. It is complementary to X-ray crystallography, NMR, and other biophysical ...
Manufactured by:Inovotion Sas based inLa Tronche, FRANCE
Pharmaceutical chemical and biology researchers need to develop new methods and models to improve the predictivity of preclinical discovery phases and increase the number of good molecules in clinic. INOVOTION’s unique in vivo technology will allow you to raise the global number of drug candidates tested in clinic without increasing your ...
Manufactured by:Inovotion Sas based inLa Tronche, FRANCE
Target validation is an essential and critical phase of the drug discovery process. This is a crucial step before starting to develop a treatment based on a targeted protein that has been identified to play a role in the disease. The target protein’s role must be clearly identified before starting to develop a drug candidate against the ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Catalysis and Reaction Mechanism Calculation: The reaction energy and reaction rate constant is analyzed through the atomic charge analysis of several important atoms participating in the reaction. In terms of complete reaction mechanism calculation, bond breaking, bond formation, transition state, and sometimes catalysis are necessarily taken into ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Strateos offers a wide range of off the shelf drug discovery assays and supports custom development of biochemical, biophysical and cell based assays in drug discovery, using both industry-standard and innovative technologies to support drug screening projects from hit identification to lead ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Identification of Rate-limiting Reaction Steps: By analyzing the structure of the reaction intermediates and transition states, the rate-limiting steps of the reaction can be determined combined with kinetic methods. Several remarkable computational methods have been developed to search for the transition states and analyze the mechanism of the entire reaction. Scientists can therefore model the ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Vibration Circular Dichroism (VCD) Spectrum Prediction: As a new method for measuring the circular dichroism of molecules in the infrared wavelength region, VCD has greatly expanded the application range of circular dichroism. Scientists use it to accurately predict chirality through conformational search and quantum chemical calculations, and the chromatogram of the vibrational circular ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Calculation of Thermodynamic Data for Individual Chemical Reactions: Thermodynamic data for chemical reactions deals with the energy change in accordance with the laws of thermodynamics. This represents macroscopic properties of the system, that is the initial and final states not involving the mechanism. It is of great benefit to understand thermodynamic properties of chemical reactions for the ...
Manufactured by:InvivoSciences, Inc. (IVS) based inMadison, WISCONSIN (USA)
Human engineered tissue (EHT)-based high content analysis can be applied to drug discovery projects at their compound screening and lead optimization stage. Mass-produced human engineered tissues will recapitulate physiological functions of native tissues in micro tissues growing in 96-well plates or 384-well plates (coming soon). ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Hit optimization is a critical step in drug discovery to funnel into lead optimization. Select the most promising hits and leverage H2L, and automated chemical synthesis workflows for faster experimental screening cycles, decreased duration and hands on time, reducing the overall drug discovery timeline leading to promising ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Strateos offers a wide range of the shelf assays and supports custom development of biochemical, biophysical and cellular assays using both industry-standard and innovative technologies to support drug discovery projects from hit identification to lead optimization. We also have broad experience in a variety of target classes ranging from GPCRs, kinases, ion ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Miniaturization is key to facilitating higher throughput, increasing reliability and accuracy and reducing costs for screening large compound libraries. We have a solid track record in miniaturizing challenging assays to 384- and 1536-well formats for medium to Ultra-High-Throughput Screening (uHTS). Strateos’ smart labs collectively span over 14K sqft and are composed of automated ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Hit discovery or hit identification in drug development is driven by the need to identify small molecules with desirable activity in a compound screen against a target. Our state-of-the-art fully automated robotic platform is set-up to accelerate your drug discovery process starting with robust, targeted hit identification ...