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Tumor Associated Antigens Services
16 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
To accelerate the development of cancer immunotherapy, it is essential to systematically identify tumor antigens that are truly tumor-specific, patient-shared, stably expressed (i. e., cloned) and immunogenic in all malignant cells. Immunopeptidomics is a large-scale and in-depth approach capable of identifying and quantifying the presented human leukocyte antigen (HLA) immunopeptidome. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens by surface T cell receptors (TCRs). Most human T cells express the classical TCRs, which consists of TCRα and TCRβ chains co-expressed with CD3 chains (γ, δ, ε, and ζ). The TCRα and TCRβ chains are composed of a variable (V) and a constant ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens by surface T cell receptors (TCRs). Most human T cells express the classical TCRs, which consists of TCRα and TCRβ chains co-expressed with CD3 chains (γ, δ, ε, and ζ). ...
Manufactured by:MuseChem based inPaoli, PENNSYLVANIA (USA)
An ADC could be divided into three main structural units: the antibody; the cytotoxic agent (drug); and the linker. The antibody has high affinity for a tumor-associated antigen that has restricted or no expression on normal cells. By combining this unique targeting capability of antibodies with the cancer-killing ability of cytotoxic drugs, ADCs ...
Manufactured by:Elpiscience based inShanghai, CHINA
Elpiscience’s proprietary discovery technologies enable efficient generation of innovative cancer ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains. Compared to αβ T cells, γδ T cells without MHC restriction on tumor antigen recognition have strong cytotoxic effects on tumor cells. γδ T cells have been considered as wonderful effector cells for cancer immunotherapy. Creative Biolabs is an excellent expert in γδ T cell research and γδ T cell ...
Manufactured by:BiomX based inNess Ziona, ISRAEL
Our colorectal cancer program utilizes engineered phage with various payloads (such as immunostimulatory payloads) that are administered intravenously to target Fusobacterium nucleatum bacteria residing within the tumor microenvironment. The aim of payload delivery is to convert cold tumors to hot tumors with activated immune responses. ...
Manufactured by:Advanced Cell Diagnostics, Inc. based inNewark, CALIFORNIA (USA)
ACD's Professional Assay Services group has been developing RNAscope™ biomarker assays for our biopharma partners for a decade. Our biomarker assays have contributed to important clinical trial exploratory endpoints, enabled more accurate patient selection, and are leading to CDx development with our partner, Leica Biosystems. Leveraging the unrivalled sensitivity and specificity of ...
Manufactured by:Immatics N.V. based inTuebingen, GERMANY
Immatics is developing Adoptive Cell Therapies, which are designed to leverage the power of T cells to actively infiltrate tumor tissue and kill tumor cells in a specific and serial ...
by:Istari Oncology Inc. based inMorrisville, NORTH CAROLINA (USA)
The tumor environment contains all the ingredients needed to mount an anticancer immune response—tumor antigens, antigen presenting cells (APCs, including tumor-associated macrophages [TAMs] and dendritic cells), and T cells—but activation of the immune system to generate that ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The immunopeptidome comprises all short peptides presented on the cell surface by HLA-I and II molecules for T-cell recognition. Immunopeptidomics analysis aims to explore the dynamics and composition of both type I and II immune peptides. Comprehensive characterization of the immunopeptidome aids in developing new therapies for cancer, immune diseases, and infectious diseases. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...
Manufactured by:Targazyme, Inc. based inCarlsbad, CALIFORNIA (USA)
TILs are part of the body’s natural response to cancer:The cells of the immune system perform immunosurveillance while circulating throughout the bodyAs part of the normal immune response, TIL migrate to the tumor site through recognition of chemokines produced by the tumor. TIL recognize tumors through tumor-specific antigens (TSAs) and can cause lysis to tumor cellsSolid tumors are ...
Manufactured by:Greenwich LifeSciences, Inc. based inHouston, TEXAS (USA)
Cancer Immunotherapies are a New Method of Cancer Treatment. Among the more established treatment options, such as surgery, chemotherapy, targeted therapy, and radiation therapy, cancer immunotherapy is a rapidly emerging and important field. It has led to new clinical research studies and has garnered the attention of biotechnology and pharmaceutical companies, regulatory agencies, payors and ...
Manufactured by:Nexelis based inSeattle, WASHINGTON (USA)
Testing Services to Support Your Preclinical and Phase I-IV Drug Programs. Nexelis, a Q² Solutions Company, provides biomarker assay services in inflammation and immunology, oncology, organ injury (renal), nutritional health, cardiovascular, metabolic (NASH/NAFLD) and infectious diseases. Our scientists approach your projects with flexible and creative solutions, developing fit-for-purpose ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Tumor immunotherapy utilizes active or passive methods to provoke tumor-specific immune responses in the body, harnessing their inhibitory and cytotoxic functions against tumor cells. Characterized by its specificity, efficacy, and mitigation of collateral damage, immunotherapy distinguishes itself from conventional methods such as surgery, targeted therapy, and ...