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Gentronix Ltd
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  5. Gentronix - OECD 487: In Vitro ...

Gentronix - OECD 487: In Vitro Micronucleus Test Service

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The in vitro micronucleus test (MNT) is a main-stay of most regulatory genotoxicity testing strategies, and is used to detect in vitro clastogens and aneugens.  In this regard it complements the Ames test well, as between the two study types they detect all of the three major classes of genotoxin. Fluorescence In Situ Hybridisation (FISH) can also be conducted to differentiate predominantly clastogenic and aneugenic modes of action.

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We have been conducting GLP in vitro MNT studies since 2014, in both isolated human lymphocytes and in TK6 cells.  We have a highly experienced team of scientists that have been running, scoring and study directing this assay type for many years.
Test systems TK6 cells, or isolated human lymphocytes

  • OECD guideline 487
  • Metabolic activation Typically induced rat liver S9, though other sources are available
  • Fluorescence In Situ Hybridisation (FISH) inclusion Available in TK6 cells
  • Test Format 3 hr +/- S9, and extended exposure -S9
  • Fluorescence microscopy pan-centromeric FISH probes, enable centromeric staining and analysis.
  • Typical test item requirements 1 - 1.5g
  • Formulation Analysis Available upon request
  • Endpoint Numerical and structural chromosomal damage