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21 applications found
Their activities have generally been established by specific cellular and molecular assays to determine mode of action. While frequently well tolerated, side-effects are nevertheless commonplace and can be the result of unexpected interference with unintended pathways in poorly understood ways. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Clinical diagnostics as e.g. measurement of bacteria in urine with a luciferase based assay of bacterial ATP can be used in the diagnosis of urinary tract infection (UTI). Screening for Duchenne’s Muscular Dystrophy (DMD) has been performed in 528,410 newborn boys in a German study. Luciferase based assays of ATP and ATP+AMP is more and more used to control hospital hygiene. ...
ByBioThema AB based in Handen, SWEDEN
With Quasi Vivo, Kirkstall’s flow system, you can quickly and easily set up and run in vitro assays to detect hepatotoxicity of novel compounds. ...
ByKirkstall Ltd. based in York, UNITED KINGDOM
The concept behind protein arrays is the immobilisation of sets of proteins, up to very large numbers, on solid supports, to perform miniaturised, multiplexed binding assays with a variety of potential ligands or interactants (see powerpoint presentation on right). ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
In recent years, however, many examples have come to light where poor validation of antibodies has led to misleading or erroneous conclusions for assays in which they are used as reagents, due to unrecognised cross-reactions and even a failure to react with their supposed target altogether. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
The Opto™ Cell Therapy Development workflow accelerates the creation of better therapeutics by performing multiple functional assays across 1,000s of individual T cells in a matter of days. Deeply characterize, profile, and map your T cell populations at the single-cell level to directly link phenotype to gene ...
ByBruker Corporation based in Billerica, MASSACHUSETTS (USA)
Methodology: The luc gene coding for firefly luciferase may be attached to another gene of interest. The expressing of this gene may then be estimated from the level of luciferase expression measured as light. This may be done in vitro, i.e. after lysing the cells adding ATP and D-luciferin, or in vivo. In the latter case D-luciferin has to enter the cells. Even whole live animals or plants may be studied, “in vivo imaging”, by injecting D-luciferin into the organism (ATP is already in the ...
ByBioThema AB based in Handen, SWEDEN
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Within the globalized pharmaceutical raw material supply chain, there is an increasing public health concern of raw material adulteration, contamination, or mislabeling, especially with recent incidents such as the adulteration of heparin. This has driven regulatory bodies to update their guidelines. Chapter 5.33 of the latest GMP guidelines for Medicinal Products for Human Use, provided by the European Commission (EC), entitled "Eudralex," specifies that "there should be appropriate procedures or measures to ...
ByGalaxy Scientific Inc based in Nashua, NEW HAMPSHIRE (USA)
Determining adverse immune responses to monoclonal ...
ByAlcyomics Ltd. based in Newcastle Upon Tyne, UNITED KINGDOM
Determine the interactome of your favourite protein. HuProt arrays provide a primary platform for screening proteins for binary interactions with the world's largest collection of human proteins immobilised on a single microarray. Over 20,000 potential interactions are assessed in a single experiment. Array screening facilitates detection of interactors with low abundance in cellular systems. Combined with other data, the array output can confirm known interactors and discover new ones, illuminating the protein ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
The new standard for quality, capacity, and speed. Deliver the best cell lines. Set your IND up for success by getting FDA-accepted monoclonality assurance in just ...
ByBruker Corporation based in Billerica, MASSACHUSETTS (USA)
Protein arrays are exposed to enzymes to identify targets for post-translational modifications. Many key protein functions require the protein to undergo a post-translational modification (PTM), examples ranging from phosphorylations and glycosylations to histone modifications and ubiquitinations. HuProt human proteome microarrays can be used for profiling the targets of enzymes producing PTMs and have been used in studies of phosphorylation, glycosylation, sumoylation, ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Increase the R&D efficiency; Multi-omics research is essential for pharmaceutical R&D, but it poses new data challenges. We help pharmaceutical companies solve these challenges in order to make R&D more efficient and go faster to ...
ByGenestack based in Cambridge, UNITED KINGDOM
Identify interacting proteins for your DNA/RNA molecule of interest. Profiling of nucleic acid binding on HuProt human proteome microarrays can reveal interactions with the largest collection of individual human proteins available on a single slide. Nucleic acid-protein interactions regulate many aspects of gene expression and thus cell physiology and pathology. DNA-protein interactions occur via a range of binding motifs present in transcription factors and nuclear receptors (e.g. DNA-binding domains, zinc ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
At Leaf, we work with our partners to help progress their research and product development into producing robust crops that can not only survive, but also flourish in a changing and challenging climate, where drought and hunger have become commonplace. We are committed to enabling our partners achieve their goals when it comes to finding answers on how to tackle feeding a growing global population. We can help facilitate their research on disease resistance, drought tolerance, pest control and growth ...
ByLeaf Expression Systems based in Colney, UNITED KINGDOM
Discover autoantigens in autoimmune diseases, delineate new candidate biomarkers. Autoantibodies are present in the blood of all healthy individuals. However, when directed at high levels against protein targets in specific tissues, autoantibodies can be a major cause of autoimmune diseases. They are also important biomarkers for diagnosis of these conditions. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Förster resonance energy transfer (FRET) is a phenomenon of non-radiative transfer of the optical excitation from an excited electronic level of one molecule, called the donor, to a resonant electronic level of another molecule, called the acceptor. In ...
ByEdinburgh Instruments - TECHCOMP Group based in , UNITED KINGDOM
Fluidity One-M by Fluidic Sciences Ltd. provides an innovative approach to studying membrane proteins without the need for traditional purification processes. This advanced instrument allows for analysis in-solution using single-use microfluidic channels, minimizing the risk of damaging delicate protein structures. It facilitates a more accurate study of protein conformation changes, ligand binding, and protein interactions in their native membrane environment. The instrument's smart assistant, Fluidity Insight, ...
ByFluidic Sciences Ltd based in Hertfordshire, UNITED KINGDOM
In the development of new drugs high throughput screening (HTS) is often used to screen large libraries of compounds for inhibitors or stimulators of various reactions. The firefly luciferase reaction can be performed reliably in a small reaction volume and is therefore highly suitable for HTS. Our Protein Kinase Kit RR can be used to measure not only protein kinase, but also all ATPases and aminoacyl tRNA synthetases. Growth inhibition from e.g. antibiotics can be measured. Gene expression can be monitored. ...
ByBioThema AB based in Handen, SWEDEN
USP37 Medical Gas requires a specific, selective and positive identification test using a paramagnetic signal. Regular analysis of medical gas is required to ensure that the oxygen concentration is NLT 99.0% volume. Following the appropriate United States Pharmacopeia standards, in this case specifically USP37, requires an analyzer which uses a paramagnetic based technology. The Systech Illinois Paramagnetic Oxgyen Analyzer PM700 is perfectly suited for this medical gas analysis ...
ByIndustrial Physics Product Integrity Limited based in Thame, UNITED KINGDOM