Biosafety Articles & Analysis
13 articles found
The unique properties of platelets including easy acquisition and strong targeting capabilities together with convenient release options and long circulation times make them ideal drug delivery carriers with weak cytotoxicity and high biosafety which enables their development into effective drug delivery systems. ...
Poly(lactic-co-glycolic acid) (PLGA) is a functional polymer organic compound randomly polymerized by lactic acid (PLA) and glycolic acid (PGA). It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material available on the market. PLGA has good biocompatibility, biodegradability, mechanical strength, good ...
In addition, degradability is an essential property of lipids that can improve biosafety and reduce cytotoxicity. And data showed that AA3-DLin can be degraded in PBS aqueous solution (pH 7.4). ...
(3) Capsid analysis of viral vectors: capsid analysis of viral vectors, including purity analysis, full/empty capsid ratio determination, genome integrity analysis, and characterization of capsid proteins. (4) Biosafety testing of viral vectors: biosafety assays for bacteria, fungi, mycoplasma, and exogenous viruses on drug materials to ensure the identity, ...
Host Cell Residual DNA (rcDNA) refers to fragments of DNA derived from host cells that may be present in biological products. These products must not contain foreign substances, particularly host DNA, to avoid immune rejection and potential threats to life safety. Regulatory agencies worldwide have imposed strict limits on the amount of rcDNA, and various pharmacopoeias have outlined several ...
Chitin is the second largest natural polymer after cellulose, and it exists widely in nature, such as shells of crustaceans such as shrimps, crabs, insects, and cell walls of fungi. Although chitin has good biocompatibility and biodegradability, its poor solubility limits its practicality in the field of biomedicine. The product of chitin deacetylation is chitosan. Chitosan is structurally ...
These data demonstrate that bacteriocin lacks an in vivo model for toxicity and biosafety studies, which are critical for advancing clinical trials. ...
Ryan Pawell is the founder and CEO of Indee Labs, a Berkeley biotech. The mission of Indee Labs is to use microfluidic vortex shedding as a scalable method to deliver CRISPR reagents into cells for developing affordable cell and gene therapies in the future. In our previous blog post, we summarized the work from their latest publication on CRISPR-editing in T cells using microfluidic devices. In ...
The institute has a high-level biosafety facility designated Biosafety Level 3 Agriculture with the ability to safely handle and study pathogens like highly pathogenic influenza viruses and the novel coronavirus. ...
As the complexity of advanced therapies continues to grow, more data is needed to establish a drug’s mode of action, efficacy, and long-term safety. It’s no wonder, then, that big data is fueling the drive for tomorrow’s therapies. However, most developers lack the in-house capabilities to produce it and/or the expertise to evaluate it. Charles River has created a complete ...
The specific questions raised by the presence of adventitious viral contaminants in these cell lines focus on the validity of conclusions obtained using these lines for basic research and the potential biosafety hazards associated with their use as substrates for biologicals manufacturing. ...
Abstract A major criticism of all-in-one workstations (sometimes known as incubated workstations or incubated glove boxes) over using traditional incubators and biosafety cabinets for cell culture is that the exposure to excessive vibration will affect cell growth and adhesion. ...
ByBaker
If biological agents may be aerosolized within the workstation, it is important that biosafety officers have containment performance data to perform a complete risk assessment. ...
ByBaker