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Bone Marrow Articles & Analysis
53 articles found
The mature ELANE enzyme is synthesized as a zymogen during neutrophil development and undergoes proteolytic activation and granule packaging within promyelocytes in the bone marrow. Its substrate specificity includes elastin, collagen, fibronectin, laminin, and various microbial proteins. ...
CXCL12, also known as stromal cell-derived factor 1 (SDF-1), is highly expressed in organs like the lungs, liver, and bone marrow—common destinations for metastatic cells. Tumors expressing high levels of the CXCR4 receptor are drawn toward these CXCL12-rich environments. ...
The blood circulation contains platelets as the second most abundant blood cell which perform multiple functions and present themselves as ideal drug carriers. The bone marrow megakaryocytes generate platelets that they release into the blood as cells without nuclei. ...
Human mesenchymal stem cells (hMSCs) are a remarkable type of stem cell found in various tissues, such as bone marrow, adipose tissue, and umbilical cord. These cells have garnered significant attention in the field of regenerative medicine and therapeutic research due to their unique properties and potential applications. ...
Platelet Membrane in Bionic Nanomedicine Platelets are little fragments of cytoplasmic material secreted from the cytoplasm of mature megakaryocytes in mammalian bone marrow. While platelets make up just between 0.5% and 1% of the total blood cells, they're central to body hemostasis. ...
Leukemia, a malignant disorder of the blood and bone marrow, poses significant challenges to both patients and healthcare providers. ...
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
Taking B-cell sequencing as an example, although 2-3% of the B-cells in the peripheral blood come from the bone marrow and spleen, this part of the cells only accounts for a very small part of the entire B-cell population. ...
Background CellRight Technologies® has developed ACTIGEN™ Verified Inductive Bone Matrix, a dehydrated, verified inductive matrix that may be hydrated with saline, blood, Bone Marrow Aspirate (BMA), Platelet Rich Plasma (PRP), or other cellular components in accordance with a physician’s well-informed medical judgment. ...
Anti-anemia APIs Anti-anemia APIs are a class of compounds that can supplement special hematopoietic components or stimulate bone marrow function for the treatment of anemia. According to different types of anemia, anti-anemia APIs are divided into iron preparations for the treatment of iron deficiency anemia (hypochromic anemia) caused by chronic blood loss, ...
Tissue grafts Due to its good biocompatibility, bioactivity and degradability, collagen has been widely studied as a tissue graft. For example, it can be used as bone repair material, tendon repair material, vascular stent and so on. ...
MSCs exhibit specific morphology, which makes them unique compared to other cell types typically used in CLD. While forming spindle-shaped, elongated, and transparent cell projections, the MSCs can pose a significant challenge when it comes to imaging and subsequent image analysis. Many imaging systems on the market are simply not fit for precise detection of these unusual cell types. ...
Hematopoiesis: Cytokines regulate the production and maturation of blood cells in the bone marrow. They stimulate the proliferation and differentiation of hematopoietic stem cells into various blood cell lineages. ...
It has been reported that LNPs loaded with siRNA can be systematically delivered to the bone marrow, but passive diffusion still presents a challenge for bone-targeted drug delivery. ...
They were initially identified in the bone marrow, but have since been found in various other tissues including adipose tissue, peripheral blood, cord blood, fallopian tube, and fetal liver and lung. ...
Introduction to OsteoporosisOsteoporosis is a systemic multi-causal skeletal disease that is prone to fractures due to changes in systemic bone mass and microstructure of bone tissue, resulting in increased bone fragility. ...
It also has an inhibitory effect on hematopoiesis of bone marrow precursor cells. Other studies suggest that IL-17D is associated with viral and tumor diseases, especially through the recruitment of natural killer cells (NK cells). ...
IL-36 beta can activate M2-like macrophages and Langerhans cells; in bone marrow dendritic cells, IL-36 stimulation leads to increased production of pro-inflammatory cytokines (such as IL-1β, IL-6, IL-12, IL-23, and TNF), which may drive innate and adaptive immune responses. ...
The clinical sample types generally include fresh or frozen tissue that often yield high quality DNA and samples that often yield low quantity and/or compromised quality DNA like FFPE (formalin-fixed paraffin-embedded) tissue, decalcified FFPE tissue, bone marrow trephines, smears, and fine needle aspirates (FNA), plasma, and circulating tumor cells. ...
There are a ton of practical uses for computer vision at present times. One industry where this technology is increasingly useful in healthcare. It is impossible to exaggerate the value of computer vision services in the medical field. Its methods continue to be used more widely since they have demonstrated excellent utility in numerous medical contexts, including surgical planning and medical ...