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Drug Stability Articles & Analysis
73 articles found
Virus-like particles (VLPs) have garnered significant attention in recent years for their potential applications in vaccine development, drug delivery, and as tools in various biotechnological fields. These nanoparticles mimic the structure of viruses but lack the viral genetic material that makes viruses infectious. ...
These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and formulators, as it aids in the development of effective ...
As seasonal allergies affect millions globally, the demand for advanced, reliable treatments is growing rapidly. Behind the scenes of this progress lies a powerful class of materials: fluoropolymers. While often associated with aerospace, semiconductor, and chemical industries, fluoropolymers also play a vital—yet underappreciated—role in pharmaceutical manufacturing, particularly in ...
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. A major challenge is loading enough drug onto each antibody without compromising solubility or circulation time. ...
This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. ...
In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. ...
ByBUCHI
This article delves into the application of nitrogen compounds in antibiotic research and development, illustrating how they influence antibiotic efficac Fundamental Properties of Nitrogen Compounds Nitrogen compounds are defined as chemical substances containing nitrogen atoms within their molecular structure. In drug chemistry, these compounds are renowned for their diverse ...
Pharmaceutical manufacturers face growing challenges in ensuring product quality, maintaining regulatory compliance, and safeguarding against counterfeit drugs. Near-infrared (NIR) spectroscopy is an important tool in this arena, offering rapid, non-destructive analysis for raw material identification, impurity detection, and counterfeit screening. By integrating NIR spectroscopy into quality ...
Understanding the metabolic stability of potential drug candidates is paramount in the realm of pharmaceutical development. ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
Linker Optimization: The linker serves a crucial function in maintaining stability, controlling drug release, and ensuring effective delivery of the cytotoxic drug. Linkers can be cleavable or non-cleavable, each with unique advantages and challenges. Their stability in circulation and the ability to release the ...
This characteristic makes them ideal for use in drug formulations that require prolonged exposure in the body. 2. Drug Loading CapacityAnother vital metric is the drug loading capacity of the copolymers. ...
The evolution of 3D printing technology has opened up new avenues in the pharmaceutical industry, especially in the fabrication of novel drug delivery systems. One such advancement is the 3D printing of Oral Thin Films (OTFs), which are ultra-thin films used to deliver drugs via oral mucosa. ...
Absorption refers to how a drug is absorbed into the bloodstream after administration. Factors influencing this process include the drug’s solubility, chemical stability, and the route of administration. ...
These excipients, such as emulsifiers, thickeners, or flavoring agents, are strategically chosen to enhance stability, improve taste, or boost bioavailability. Ensuring the stability and bioavailability of the drug substance in a liquid environment remains a cornerstone of formulation science, demanding specific expertise and technological ...
Role of Liposomes in Drug Delivery The structure of liposomes, consisting of an aqueous core enclosed by a lipid bilayer, allows for the encapsulation of both hydrophilic and lipophilic drugs. ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates, etc. ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. ...
Therefore, by measuring the intrinsic fluorescence of recombinant protein vaccines, it is possible to obtain information about their structure and monitor possible denaturation during the preparation and storage processes, thus assessing the stability of recombinant protein vaccines.The detection of the intrinsic fluorescence of recombinant protein vaccines is typically carried ...
They are designed to overcome limitations associated with peptides, such as poor stability and bioavailability by preserving or enhancing their functions. ...